酒精性肝病的研究进展  

Progress in research of alcoholic liver disease

作　　者：曾赏 李三强[1] 李前辉[2] Shang Zeng;San-Qiang Li;Qian-Hui Li(Molecular Medicine Key Laboratory of Liver Injury and Repair Medical College,Henan University of Science and Technology,Henan Center for Engineering and Technology Research on Prevention and Treatment of Liver Diseases,Luoyang 471003,Henan Province,China;The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471003,Henan Province,China)

机构地区：[1]河南科技大学基础医学院肝脏损伤与修复分子医学重点实验室,河南省肝病防治工程技术研究中心,河南省洛阳市471003 [2]河南科技大学第一附属医院,河南省洛阳市471003

出　　处：《世界华人消化杂志》2022年第12期535-540,共6页World Chinese Journal of Digestology

基　　金：洛阳市科技计划项目,No.2101030A.

摘　　要：酒精性肝病(alcoholic liver disease,ALD)是指因过度饮酒而对肝脏及其功能造成的损伤,它包括酒精性脂肪肝/脂肪变性、酒精性肝炎、酒精性肝纤维化或肝硬化,甚至是肝细胞癌.然而,由于酒精及其代谢产物的毒性作用、免疫反应、氧化应激、细胞自噬、肠道微生物、遗传因素和非编码RNA等的参与,酒精性肝病的发病机制尤为复杂.因此,本文就近年来对ALD发病机制新进展进行综述,以进一步了解ALD的分子机制,并对其临床治疗提出展望.Alcoholic liver disease(ALD)refers to the damage to the liver and its functions that result from excessive drinking,including alcoholic fatty liver/steatosis,alcoholic hepatitis,alcoholic liver fibrosis or cirrhosis,and even hepatocellular carcinoma.However,the pathogenesis of ALD is particularly complex due to the involvement of the toxic effects of alcohol and its metabolites,immune reaction,oxidative stress,autophagy,intestinal microbes,genetic factors,non-coding RNAs,etc.This paper reviews the new progress in the understanding of the pathogenesis and molecular mechanism of ALD,and provides perspectives on its clinical treatment.

关 键 词：酒精性肝病 发病机制 治疗学 

分 类 号：R575.5[医药卫生—消化系统]