广西某三甲医院妇科门诊患者HPV感染情况及HPV疫苗认知情况调查分析  

Investigation and analysis on human papilloma virus infection and cognition on vaccines in the gynecological clinic of an AAA hospital in Guangxi

作　　者：张琪 汤海燕 刘浩瀚 林明[1] 韦宏旷 ZHANG Qi;TANG Hai-yan;LIU Hao-han;LIN Ming;WEI Hong-kuang(Maternity and Child Health Care of Guangxi Zhuang Autonomous Region,Nanning 530003,China)

机构地区：[1]广西壮族自治区妇幼保健院,南宁530003

出　　处：《医学动物防制》2022年第6期517-521,共5页Journal of Medical Pest Control

基　　金：广西自然科学基金(2013GXNSFAA019256)。

摘　　要：目的了解广西某三甲医院妇科门诊就诊患者人乳头瘤病毒(human papilloma virus,HPV)感染及其基因型分布情况,及HPV疫苗认知程度,为进一步开展宫颈癌防治提供依据。方法选取2018年1月—2019年12月在广西某三甲医院妇科门诊行HPV检测的3048例患者作为研究对象,通过问卷星软件制作生成问卷二维码,采用整群抽样方法开展HPV及HPV疫苗认知情况调查。结果某三甲医院妇科门诊就诊患者HPV感染率为17.75%,其中高危型为14.73%、低危型为3.02%,20~30岁和>60岁患者HPV感染率高于其他年龄患者,差异有统计学意义(χ^(2)=16.39,P<0.01);HPV基因型分布中高危型占82.47%,其中52、16、58、53和39型检出率较高,分别占高危型总数的22.15%、14.09%、11.19%、8.05%和6.26%;就诊患者HPV及HPV疫苗知晓率分别为35.97%、48.39%,不同年龄、婚姻状况、居住地、职业以及受教育程度的患者对HPV及HPV疫苗认知程度不同,差异均有统计学意义(HPV:χ^(2)=93.16、7.07、210.77、74.76、64.23,HPV疫苗:χ^(2)=27.89、37.48、175.78、142.04、228.83,P均<0.01);76.24%的患者愿意接种HPV疫苗,14.84%的患者明确不愿接种HPV疫苗;网络是获取相关信息的主要途径,占33.78%,其次为电视/报纸/杂志,占30.56%,而从医生获知的占25.22%。结论广西某三甲医院妇科门诊就诊患者HPV感染以高危型为主,部分患者对HPV基础知识及疫苗相关知识缺乏了解。应加大HPV普查力度,积极推广HPV疫苗的知晓率和接受度。Objective To understand the distribution of human papilloma virus(HPV)infection and knowledge for HPV and HPV vaccine in the gynecological clinic of an AAA hospital in Guangxi,and to provide evidence for the prevention and treatment of cervical cancer.Methods A total of 3048 patients receiving HPV tests in the gynecological clinic of an AAA hospital in Guangxi from January 2018 to December 2019 were selected,and the cognition on HPV and corresponding vaccines were investigated by quick response(QR)-based code questionnaire with the cluster sampling method.Results The infection rate of HPV in patients visiting the gynecological clinic of an AAA hospital was 17.75%;the rate of high-risk and low-risk subtype infections were 14.73%and 3.02%,respectively.The infection rate of HPV in patients aged 20-30 and>60 years old were higher than that in other age groups,and the difference was statistically significant(χ^(2)=16.39,P<0.01).In the distribution of HPV genotypes,high-risk HPV accounted for 82.47%,the positive rate of 52,16,58,53 and 39 were higher,accounting for 22.15%,14.09%,11.19%,8.05%and 6.26%,respectively.The cognition rate for HPV and HPV vaccine in visiting patients was 35.97%and 48.39%,respectively.Patients with different ages,marital statuses,residences,occupations and education levels threw different cognitions for HPV and HPV vaccine,and the differences were statistically significant(HPV:χ^(2)=93.16,7.07,210.77,74.76,64.23,HPV vaccine:χ^(2)=27.89,37.48,175.78,142.04,228.83,P<0.01);76.24%of patients were willing to receive HPV vaccine,and 14.84%affirmatively denied being vaccinated with HPV vaccine.Internet was found to be major route to acquire related information,accounting for 33.78%,followed by TV/newspaper/magazine with the percent of 30.56%,and the cognition rate from physician accounted for 25.22%.Conclusion High-risk subtypes of HPV infection dominate in the gynecological clinic of an AAA hospital,and some patients lack understandings on HPV-related knowledge.The intensity of general screening o

关 键 词：妇科门诊 患者 宫颈癌 人乳头瘤病毒 基因型 疫苗 

分 类 号：R737.33[医药卫生—肿瘤]