华蟾素注射液腹腔灌注治疗结肠癌恶性腹水疗效的影响因素分析  

Analysis on influencing factors of Huachansu Injection intraperitoneal perfusion in treating colon cancer with malignant ascites

作　　者：王一同 马若凡 武煜 周琴[3] 左明焕[3] WANG Yitong;MA Ruofan;WU Yu;ZHOU Qin;ZUO Minghuan(Beijing University of Chinese Medicine,Beijing 100029,China;Beijing Youan Hospital,Capital Medical University,Beijing 100069,China;Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学,北京100029 [2]首都医科大学附属北京佑安医院,北京100069 [3]北京中医药大学东方医院,北京100078

出　　处：《上海中医药大学学报》2022年第3期20-24,共5页Academic Journal of Shanghai University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81373832);首都医科大学附属北京佑安医院中青年人才孵育项目(YNKYQN2021012)。

摘　　要：目的:探讨华蟾素注射液腹腔灌注治疗结肠癌恶性腹水患者疗效的影响因素,总结优效人群特征,以更好地指导临床用药。方法:采用回顾性研究方法,收集135例采用华蟾素注射液腹腔灌注治疗的结肠癌恶性腹水患者的临床资料。以腹水量控制疗效及腹水颜色改善疗效为结局指标,采用logistic回归分析探讨性别、年龄、腹水性质、中医辨证分型等因素对疗效的影响。结果:135例患者中,腹水量控制有效者83例,腹水颜色改善有效者94例。logistic回归分析结果显示,结肠癌原发部位、腹水性质、是否合并全身中医治疗是影响腹水量控制疗效的独立因素,有无肝转移、腹水性质、有无胆红素升高、局部辨证是影响腹水颜色改善疗效的独立因素。结论:运用华蟾素注射液腹腔灌注治疗结肠癌恶性腹水,可能对原发于左半结肠、无肝转移、无胆红素升高、血性腹水、局部辨证为湿热毒证、合并使用全身中医治疗的患者疗效较好,临床中可通过人群特征初步筛选后用药,有望提高疗效。Objective:To explore the influencing factors of Huachansu Injection intraperitoneal perfusion in treating patients of colon cancer with malignant ascites and summarize the characteristics of the benefit population,in order to better guide the clinical medication.Methods:A retrospective study was applied,and the clinical data of 135 patients of colon cancer with malignant ascites treated by Huachansu Injection intraperitoneal perfusion were collected. Taking the ascites volume control efficacy and the ascites color improvement efficacy as the outcome indexes,the logistic regression analysis was conducted to investigate the influences of the factors including gender,age,ascites property,Chinese medicial syndrome and other factors on the efficacy.Results:Among the 135 patients,the ascites volume control was effective in 83 cases and the ascites color improvement was effective in 94 cases. The results of logistic regression analysis showed that,the primary location of colon cancer,ascites property and combining with systemic Chinese medicine treatment were the independent influencing factors on the ascites volume control efficacy,and liver metastasis,ascites property,increased bilirubin and local syndrome differentiation were the independent influencing factors on the ascites color improvement efficacy.Conclusion:Huachansu Injection intraperitoneal perfusion has better effect in the treatment of colon cancer with malignant ascites for the patients whose primary location are left colon,without liver metastasis and increased bilirubin,with bloody ascites and dampness-heat toxicity syndrome of local syndrome differentiation,treated by combining with systematic Chinese medicine. Through the preliminary screening of population characteristics before treatment,the clinical efficacy might be improved.

关 键 词：恶性腹水 结肠癌 华蟾素注射液 影响因素 回顾性分析 

分 类 号：R735.35[医药卫生—肿瘤]