纳米碳示踪技术与超声造影术对甲状腺癌手术患者近期结局的影响  

Influence of nanocarbon tracer technology vs contrast-enhanced ultrasonography on short-term outcomes of patients with thyroid cancer undergoing surgery

作　　者：王平云[1] 杨贺庆[1] 葛昆朋 Wang Pingyun;Yang Heqing;Ge Kunpeng(Department of General Surgery,Qinhuangdao Second Hospital,Qinhuangdao 066600,China)

机构地区：[1]秦皇岛市第二医院普外科,秦皇岛066600

出　　处：《中华生物医学工程杂志》2022年第1期43-48,共6页Chinese Journal of Biomedical Engineering

摘　　要：目的比较纳米碳示踪技术与超声造影术对甲状腺癌手术患者近期结局的影响。方法选择我院2019年9月至2020年9月间收治的80例甲状腺癌手术患者, 随机分为对照组和试验组, 各40例。所有患者均采取甲状腺癌手术治疗, 对照组术中采用纳米碳淋巴结示踪技术进行辅助, 试验组术中采用超声造影术辅助。比较两组手术时间、术中出血量、术后手术切口引流量、术后住院时间、淋巴结清除数目、癌转移例数、术后声音嘶哑例数、甲状旁腺误切例数, 术后1、3、5、7 d及3个月血清Ca2+浓度及PTH浓度变化, 术后3个月甲状旁腺受损症状发生情况。结果试验组平均淋巴结清除数目(8.14±2.13)少于对照组(9.37±2.24), 阳性淋巴结清扫率(97.50%)高于对照组(82.50%), 均P<0.05;两组手术时间(117.93±17.46 vs 115.34±15.68)min、术中出血量(47.33±10.46 v 46.74±12.63)ml、术后切口引流量(34.77±6.57 vs 36.32±5.89)ml、术后住院时间(6.76±1.54 vs 7.15±1.62)d、癌转移例数(17.50% vs 15.00%)、术后声音嘶哑例数(25.00% vs 30.00%)及甲状旁腺误切例数(7.50% vs 15.00%)差异无统计学意义(P>0.05);两组术后1 d、3 d、7d血清Ca2+及PTH浓度均低于术前(P<0.05), 术后3个月时血清Ca2+及PTH浓度与术前比较差异均无统计学意义(P>0.05);两组血清Ca2+及PTH浓度组间比较差异无统计学意义(P>0.05);两组术后手足抽搐、四肢麻木、肌肉痉挛及肢体感觉异常等发生率差异无统计学意义(P>0.05)。结论超声造影术对阳性淋巴结清扫率优于纳米碳示踪技术, 但两者在缓解术后血清Ca2+及PTH浓度降低程度, 减少甲状旁腺受损症状, 保护甲状腺功能等的效果相当。Objective To compare the effect of nanocarbon tracer technology vs contrast-enhanced ultrasonography on short-term outcomes of patients with thyroid cancer undergoing surgery.Methods A total of 80 patients with thyroid cancer treated in our hospital between September 2019 and September 2020 were recruited and randomly divided into the control group and the study group(n=40 each).All patients underwent surgical treatment for thyroid cancer,assisted by nano-carbon tracer technology(control group)or contrast-enhanced ultrasonography(study group)for lymph node localization.The operation time,intraoperative blood loss,volume of postoperative incision drainage,length of postoperative hospital stay,number of lymph nodes dissected,numbers of metastatic patients,patients with postoperative hoarseness and patients with inadvertant parathyroidectomy,changes in serum Ca2+and parathyroid hormone(PTH)levels at 1,3,5,7 days and at 3 months after surgery,and symptoms of parathyroid injury at 3 months after surgery,were compared between the two groups.Results The mean number of lymph nodes dissected was smaller in the study group(8.14±2.13)than that in the control group(9.37±2.24),but the ratio of positive lymph node dissection was higher in the control group(97.50%)than that in the control group(82.50%)(both P<0.05).There were no significant differences between the two groups in operation time(117.93±17.46 vs 115.34±15.68 min),intraoperative blood loss(47.33±10.46 v 46.74±12.63 mL),volume of postoperative incision drainage(34.77±6.57 vs 36.32±5.89 mL),length of postoperative hospital stay(6.76±1.54 vs 7.15±1.62 d),proportions of metastatic patients(17.50%vs 15.00%),patients with postoperative hoarseness(25.00%vs 30.00%)and patients with inadvertent parathyroidectomy(7.50%vs 15.00%)(all P>0.05).The serum Ca2+and PTH levels in either group were lower than baseline at 1,3,and 7 d after surgery(P<0.05).There was no significant difference in serum Ca2+or PTH level at 3 months after surgery compared with baseline in either g

关 键 词：超声外科手术 甲状腺肿瘤 预后 纳米碳 

分 类 号：R736.1[医药卫生—肿瘤]