Effect of ulinastatin on the inflammatory response after video-assisted thoracic lobectomy in patients with lung cancer:a randomized controlled study  

作　　者：Won Jung Hwang Min A.Joo Jin Joo 

机构地区：[1]Department of Anesthesiology and Pain Medicine,Seoul St.Mary’s Hospital,College of Medicine,The Catholic University of Korea,Seoul,Republic of Korea

出　　处：《Chinese Medical Journal》2022年第7期806-812,共7页中华医学杂志（英文版）

基　　金：Catholic Medical Center Research(5-2018-B0001-00004)。

摘　　要：Background:The first-line treatment for lung cancer is surgical resection,and one-lung ventilation(OLV)is the most basic anesthetic management method in lung surgery.During OLV,inflammatory cytokines are released in response to the lung tissue damage and promote local and contralateral lung damage through the systemic circulation.We designed a randomized,prospective study to evaluate the effect of the urinary trypsin inhibitor(UTI)ulinastatin on the inflammatory response after video-assisted thoracic lobectomy in patients with lung cancer.Methods:Adult patients aged 19 to 70 years,who were scheduled for video-assisted thoracic lobectomy surgery to treat lung cancer between May 2020 and August 2020,were enrolled in this randomized,prospective study.UTI(300,000 units)mixed with 100 mL of normal saline in the ulinastatin group and 100 mL of normal saline in the control group was administered over 1 h after inducing anesthesia.Results:The baseline(T0)interferon-γ(IFN-γ)/interleukin-4(IL-4)ratio was not different between the groups(6941.3±2778.7vs.6954.3±2752.4 pg/mL,respectively;P>0.05).The IFN-γ/IL-4 ratio was significantly higher in ulinastatin group at 30 min after entering the recovery room than control group(20,148.2±5054.3vs.6674.0±2963.6,respectively;adjustedP<0.017).Conclusion:Administering UTI attenuated the anti-inflammatory response,in terms of INF-γexpression and the IFN-γ/IL-4 ratio,after video-assisted thoracic surgery in lung cancer patients.Trial registration:Clinical Research Information Service of Korea National Institute of Health(CRIS),KCT0005533.

关 键 词：ULINASTATIN Lung cancer Video-assisted thoracic surgery INF-Γ IL-4 

分 类 号：R734.2[医药卫生—肿瘤]