Managements of osteoporotic vertebral compression fractures:A narrative review  

作　　者：Devon Patel Jiayong Liu Nabil A Ebraheim 

机构地区：[1]College of Medicine and Life Sciences,University of Toledo,Toledo,OH 43614,United States [2]Department of Orthopedic Surgery,University of Toledo Medical Center,Toledo,OH 43614,United States

出　　处：《World Journal of Orthopedics》2022年第6期564-573,共10页世界骨科杂志（英文版）

摘　　要：Osteoporotic vertebral compression fractures(OVCFs)are the most common fragility fracture and significantly influence the quality of life in the elderly.Currently,the literature lacks a comprehensive narrative review of the management of OVCFs.The purpose of this study is to review background information,diagnosis,and surgical and non-surgical management of the OVCFs.A comprehensive search of PubMed and Google Scholar for articles in the English language between 1980 and 2021 was performed.Combinations of the following terms were used:compression fractures,vertebral compression fractures,osteoporosis,osteoporotic compression fractures,vertebroplasty,kyphoplasty,bisphosphonates,calcitonin,and osteoporosis treatments.Additional articles were also included by examining the reference list of articles found in the search.OVCFs,especially those that occur over long periods,can be asymptomatic.Symptoms of acute OVCFs include pain localized to the mid-line spine,a loss in height,and decreased mobility.The primary treatment regimens are pain control,medication management,vertebral augmentation,and anterior or posterior decompression and reconstructions.Pain control can be achieved with acetaminophen or nonsteroidal anti-inflammatory drugs for mild pain or opioids and/or calcitonin for moderate to severe pain.Bisphosphonates and denosumab are the first-line treatments for osteoporosis.Vertebroplasty and kyphoplasty are reserved for patients who have not found symptomatic relief through conservative methods and are effective in achieving pain relief.Vertebroplasty is less technical and cheaper than kyphoplasty but could have more complications.Calcium and vitamin D supplementation can have a protective and therapeutic effect.Management of OVCFs must be combined with multiple approaches.Appropriate exercises and activity modification are important in fracture prevention.Medication with different mechanisms of action is a critical long-term causal treatment strategy.The minimally invasive surgical interventions such as verteb

关 键 词：Vertebral body OSTEOPOROSIS Fragility fractures Osteoporotic vertebral compression fractures KYPHOPLASTY VERTEBROPLASTY 

分 类 号：R687.3[医药卫生—骨科学]