DNA and RNA oxidative damage in hepatocellular carcinoma patients and mortality during the first year of liver transplantation  

作　　者：Leonardo Lorente Sergio T Rodriguez Pablo Sanz Agustín F González-Rivero Antonia Pérez-Cejas Javier Padilla Dácil Díaz Antonio González María M Martín Alejandro Jiménez Purificación Cerro Julián Portero Manuel A Barrera 

机构地区：[1]Department ofIntensive Care,Hospital Universitario de Canarias,La Laguna 38320,Tenerife,Spain [2]Intensive Care Unit,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz de Tenerife 38010,Spain [3]Department of Surgery,Hospital Universitario Nuestra Señora de Candelaria,Santa Cruz de Tenerife 38010,Spain [4]Department of Laboratory,Hospital Universitario de Canarias,La Laguna 38320,Spain [5]Department of Digestive,Hospital Universitario Nuestra Señora de Candelaria,Santa Cruz de Tenerife 38010,Spain [6]Research Unit,Hospital Universitario de Canarias,La Laguna 38320,Spain [7]Transplant Unit,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz de Tenerife 38010,Spain [8]Department of Radiology,Hospital Universitario Nuestra Señora Candelaria,Santa Cruz de Tenerife 38010,Spain

出　　处：《World Journal of Hepatology》2022年第6期1182-1189,共8页世界肝病学杂志（英文版）（电子版）

摘　　要：BACKGROUND Oxidative damage of DNA and RNA has been associated with mortality of patients with different diseases.However,there is no published data on the potential use of DNA and RNA oxidative damage to predict the prognosis of patients with hepatocellular carcinoma(HCC)undergoing liver transplantation(LT).AIM To determine whether patients with increased DNA and RNA oxidative damage prior to LT for HCC have a poor LT prognosis.METHODS Patients with HCC who underwent LT were included in this observational and retrospective study.Serum levels of all three oxidized guanine species(OGS)were measured prior to LT since guanine is the nucleobase that forms DNA and RNA most prone to oxidation.LT mortality at 1 year was the end-point study.RESULTS Surviving patients(n=101)showed lower serum OGS levels(P=0.01)and lower age of the liver donor(P=0.03)than non-surviving patients(n=13).An association between serum OGS levels prior to LT and 1-year LT(odds ratio=2.079;95%confidence interval=1.356-3.189;P=0.001)was found in the logistic regression analysis.CONCLUSION The main new finding was that high serum OGS concentration prior to LT was associated with the mortality 1 year after LT in HCC patients.

关 键 词：DNA oxidative damage Hepatocellular carcinoma Liver transplantation MORTALITY Oxidized guanine species 

分 类 号：R735.7[医药卫生—肿瘤]