Role of transcribed ultraconserved regions in gastric cancer and therapeutic perspectives  

作　　者：Shen-Shuo Gao Zhi-Kai Zhang Xu-Bin Wang Yan Ma Guo-Qing Yin Xiao-Bo Guo 

机构地区：[1]Department of Gastrointestinal Surgery,Shandong Provincial Hospital,Cheeloo College of Medicine,Shandong University,Jinan 250021,Shandong Province,China [2]Department of Gastrointestinal Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,Shandong Province,China [3]Department of Anus and Intestine Surgery,Qingzhou Hospital Affiliated to Shandong First Medical University,Qingzhou 262500,Shandong Province,China

出　　处：《World Journal of Gastroenterology》2022年第25期2900-2909,共10页世界胃肠病学杂志（英文版）

基　　金：Supported by National Natural Science Foundation of China,No.81672379 and No.81101858;Natural Science Foundation of Shandong Province,China,No.ZR2016HM16.

摘　　要：Gastric cancer(GC)is the fourth leading cause of cancer-related death.The occurrence and development of GC is a complex process involving multiple biological mechanisms.Although traditional regulation modulates molecular functions related to the occurrence and development of GC,the comprehensive mechanisms remain unclear.Ultraconserved region(UCR)refers to a genome sequence that is completely conserved in the homologous regions of the human,rat and mouse genomes,with 100%identity,without any insertions or deletions,and often located in fragile sites and tumour-related genes.The transcribed UCR(T-UCR)is transcribed from the UCR and is a new type of long noncoding RNA.Recent studies have found that the expression level of T-UCRs changes during the occurrence and development of GC,revealing a new mechanism underlying GC.Therefore,this article aims to review the relevant research on T-UCRs in GC,as well as the function of T-UCRs and their regulatory role in the occurrence and development of GC,to provide new strategies for GC diagnosis and treatment.

关 键 词：Transcribed ultraconserved region Gastric cancer Development Function Therapeutic perspectives 

分 类 号：R735.2[医药卫生—肿瘤]