Malignant histiocytosis associated with mediastinal germ cell tumor:A case report  

作　　者：Pei-Yi Yang Xiao-Li Ma Wen Zhao Li-Bing Fu Rui Zhang Qi Zeng Hong Qin Tong Yu Yan Su 

机构地区：[1]Department of Medical Oncology,Pediatric Oncology Center,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [2]Department of Pathology,Beijing Children’s Hospital,Capital Medical University,National Center of Children’s Health,Beijing 100045,China [3]Hematology Center,Beijing Children’s Hospital,Capital Medical University,National Center of Children’s Health,Beijing 100045,China [4]Department of Thoracic Surgery,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing 100045,China [5]Department of Surgical Oncology,Capital Medical University,National Center for Children’s Health,Beijing 100045,China [6]Department of Image Center,Beijing Children’s Hospital,Capital Medical University,National Center of Children’s Health,Beijing 100045,China

出　　处：《World Journal of Clinical Cases》2022年第20期7116-7123,共8页世界临床病例杂志

摘　　要：BACKGROUND Germ cell tumors(GCTs)account for 2%of human malignancies but are the most common malignant tumors among males aged 15-35.Since 1983,an association between mediastinal GCT(MGCT)and hematologic malignancies has been recognized.CASE SUMMARY We report a case in which malignant histiocytosis was associated with mediastinal GCTs.The clinical data of a male patient with MGCT admitted to Beijing Children's Hospital were collected retrospectively.The patient was first diagnosed according to imaging and pathological features as having MGCT,and was treated with surgery and chemotherapy.One year after stopping chemotherapy,imaging showed metastases in the right supraclavicular,mediastinum,hilar region and retroperitoneal lymph node,right pleura,right lung,and right para-cardiac margin.Pathological diagnosis of the liver nodular and hilar lymph nodes included systemic juvenile xanthogranuloma and Rosai-Dorfman lesions with malignant transformation(i.e.,morphological characteristics and immunophenotype of histiocytic sarcoma).Following diagnosis,the patient accepted chemotherapy with vindesine,cytarabine and dexamethasone.Positron emission tomography–computed tomography showed partial remission.The patient was followed-up for 10 mo after the diagnosis of malignant histiocytosis,and no sign of progression or relapse was observed.CONCLUSION Physicians should recognize the possibility of hematologic malignancies being associated with MGCT.Suitable sites should be selected for pathological examination.

关 键 词：Germ cell tumor MEDIASTINAL Malignant histiocytosis Histiocytic sarcoma Hematologic malignancies Case report 

分 类 号：R734.5[医药卫生—肿瘤]