Tumor-to-tumor metastasis of clear cell renal cell carcinoma to contralateral synchronous pheochromocytoma:A case report  

作　　者：Hsin-Yu Wen Jing Hou Hao Zeng Qiao Zhou Ni Chen 

机构地区：[1]Department of Pathology,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Department of Urology,West China Hospital of Sichuan University,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2022年第19期6750-6758,共9页世界临床病例杂志

基　　金：the National Natural Science Foundation of China,No.NSFC 81872107 and No.NSFC 81872108。

摘　　要：BACKGROUND Tumor-to-tumor metastasis(TTM)is an uncommon condition.Only a few cases of renal cell carcinoma(RCC)as donor tumor of TTM have been reported in literature,and none of these studies have described RCC metastasizing to synchronous pheochromocytoma(PCC).CASE SUMMARY The patient was a 54-year-old woman who presented with recurrent dull abdominal pain for six months,which was further aggravated for one more month.Enhanced computed tomography revealed a tumor mass in the right kidney and another mass in the left retroperitoneum/adrenal gland.Histopathology and immunochemistry of resected specimens confirmed the diagnosis of clear cell renal cell carcinoma(CCRCC)of the right kidney,and the left retroperitoneum revealed a typical PCC with CCRCC metastasis.Whole exome sequencing revealed the presence of a c.529A>T somatic mutation of the Von Hippel Lindau(VHL)gene in the metastasized CCRCC,which was also present in the primary right kidney CCRCC,as confirmed by Sanger sequencing.No VHL mutation was detected in the PCC or in normal right kidney tissue.Fluorescence in situ hybridization revealed loss of chromosome 3p in both the primary right kidney CCRCC and CCRCC metastasized to PCC in the left kidney.CONCLUSION This is the first case showing metastasis of CCRCC to PCC,thus leading to tumorto-tumor metastasis.

关 键 词：Tumor-to-tumor metastasis Clear cell renal cell carcinoma PHEOCHROMOCYTOMA Von Hippel Lindau somatic mutation Case report 

分 类 号：R737.11[医药卫生—肿瘤]