Efficacy and mechanism of anti-vascular endothelial growth factor drugs for diabetic macular edema patients  

作　　者：Yun-Fei Li Qian Ren Chao-Hui Sun Li Li Hai-Dong Lian Rui-Xue Sun Xian Su Hua Yu 

机构地区：[1]Department of Ophthalmology,Shijiazhuang City People’s Hospital,Shijiazhuang 050031,Hebei Province,China [2]Department of Ophthalmology,The First Affiliated Hospital of Shihezi University School of Medicine,Shihezi 832061,Xinjiang Uygur Autonomous Region,China

出　　处：《World Journal of Diabetes》2022年第7期532-542,共11页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND Diabetes is a serious public health concern in China,with 30%of patients developing retinopathy,and diabetic macular edema(DME)having the biggest impact on vision.High blood glucose level can cause retinal cell hypoxia,thus promoting vascular endothelial growth factor(VEGF)formation and increasing vascular permeability,which induces DME.Moreover,cell hypoxia can accelerate the rate of apoptosis,which leads to the aging of patients.In severe cases,optic cell apoptosis or retinal fibrosis and permanent blindness may occur.AIM To investigate and compare the efficacy,mechanism,and differences between two anti-VEGF drugs(Compaq and ranibizumab)in DME patients.METHODS Ninety-six patients with DME who attended our hospital from April 2018 to February 2020 were included and randomly divided into two groups(Compaq group and ranibizumab group).The groups received vitreal cavity injections of 0.5 mg Compaq and 0.5 mg ranibizumab,respectively,once a month.The best corrected visual acuity(BCVA),intraocular pressure(IOP),macular retinal thickness(CMT),macular choroidal thickness(SFCT),foveal no perfusion area(FAZ),superficial capillary density,deep capillary density,treatment effect,and adverse reactions were compared before and after treatment and between the two groups.RESULTS Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated BCVA in both groups(P>0.05).BCVA decreased in the Compaq group 3 mo after treatment,and the difference was statistically significant(P<0.05).Before treatment,and 1 mo and 3 mo post-treatment,there was no statistically significant difference in the estimated IOP in either group(P>0.05).Before treatment and 1-mo post-treatment,there was no statistically significant difference in the estimated CMT,SFCT,or FAZ in either group(P>0.05).CMT and SFCT values decreased in the Compaq group 3 mo post-treatment,and the difference was statistically significant(P<0.05).Before treatment,and 1 mo and 3 mo post-treatment,there were no statistically sign

关 键 词：Diabetic macular edema Vascular endothelial growth factor COMPAQ RANIBIZUMAB Optimally correct vision DIABETES 

分 类 号：R587.2[医药卫生—内分泌] R774.5[医药卫生—内科学]