Elevated levels of fructosamine are independently associated with SARS-CoV-2 reinfection:A 12-mo follow-up study  

作　　者：Xiao-Yan Huang Li-Juan Yang Xiang Hu Xing-Xing Zhang Xiao Gu Lin-Jia Du Zhi-Ying He Xue-Jiang Gu 

机构地区：[1]Department of Endocrine and Metabolic Disease,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,Zhejiang Province,China [2]Department of Endocrine and Metabolic Disease,Yueqing People’s Hospital,Affiliated Hospital of Wenzhou Medical University,Wenzhou 325600,Zhejiang Province,China

出　　处：《World Journal of Diabetes》2022年第7期543-552,共10页世界糖尿病杂志（英文版）（电子版）

摘　　要：BACKGROUND The association between blood levels of fructosamine(FMN)and recurrent coronavirus disease 2019(COVID-19)is currently unclear.AIM To investigate a prospective relationship between blood levels of FMN and severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reinfection.METHODS A total of 146 Chinese hospitalized patients infected with SARS-CoV-2 were consecutively collectively recruited and followed from January 2020 to May 2021.Diagnosis of COVID-19 and SARS-CoV-2 reinfection was based on the diagnostic criteria and treatment protocol in China.The levels of FMN were determined in blood and divided into tertiles based on their distribution in the cohort of COVID-19 patients.Multivariate-adjusted hazard ratios(HRs)with 95%confidence intervals(CIs)were estimated for SARS-CoV-2 reinfection across the tertiles of FMN levels.A Cox regression model was used to generate the HR for SARS-CoV-2 reinfection in the participants in the top tertile of FMN levels compared with those at the bottom.Disease-free survival was used as the time variable,and relapse was used as the state variable,adjusted for age,gender,influencing factors such as diabetes mellitus,hypertension,and corticosteroid therapy,and clinical indexes such as acute liver failure,acute kidney failure,white blood cell(WBC)count,C-reactive protein,prognostic nutritional index(PNI),and blood lipids.Kaplan-Meier analysis with log-rank tests was used to compare the survival rate between patients with elevated FMN levels(FMN>1.93 mmol/L,the top tertile)and those with nonelevated levels.RESULTS Clinical data for the 146 patients with confirmed COVID-19[age 49(39-55)years;49%males]were analyzed.Eleven patients had SARS-CoV-2 reinfection.The SARS-CoV-2 reinfection rate in patients with elevated FMN levels was significantly higher than that in patients with nonelevated FMN(17%vs 3%;P=0.008)at the end of the 12-mo follow-up.After adjustments for gender,age,diabetes mellitus,hypertension,corticosteroid therapy,WBC count,PNI,indexes of liver and renal functio

关 键 词：FRUCTOSAMINE COVID-19 REINFECTION BLOOD 

分 类 号：R511.9[医药卫生—内科学]