Chronic urticaria associated with lung adenocarcinoma—a paraneoplastic manifestation:A case report and literature review  

作　　者：Luisa Fernanda Jiménez Evis Adriana Castellón Juan David Marenco JoséMaria Mejía Camilo Andrés Rojas Franklin Torres Jiménez Linda Coronell Estefanie Osorio-Llanes Evelyn Mendoza-Torres 

机构地区：[1]Faculty of Health Sciences,Universidad Libre de Colombia,Seccional Barranquilla,Barranquilla 08000,Colombia [2]Faculty of Exact and Natural Sciences,Universidad Libre de Colombia,Seccional Barranquilla,Barranquilla 08000,Colombia [3]lty of Health Sciences,Universidad Libre De Colombia,Seccional Barranquilla,Barranquilla 08000,Atlántico,Colombia

出　　处：《World Journal of Clinical Cases》2022年第21期7553-7564,共12页世界临床病例杂志

摘　　要：BACKGROUND Urticaria is one of the most common causes of emergency room visits.It is defined as an acute inflammatory dermatosis,characterized by localized degranulation of mast cells,with consequent dermal microvascular and formation of edematous and pruritic plaques called hives.Urticaria affects the skin and tissues of the superficial mucosa.Sometimes it is accompanied by angioedema,which is characterized by deeper edema of the dermis and subcutaneous cellular tissue known as the urticarial-angioedema syndrome.About 15%-25%of the general population has suffered at least one type of urticaria at some point during their lifetime and hyperpermeability estimated at 7.6%-16%and has experienced acute urticaria that is usually self-limited and spontaneously resolves without requiring medical attention.CASE SUMMARY We present the case of a young male patient who was referred to our department with a clinical picture of 4 mo of pruritus associated with hives of variable sizes,irregular borders,with interlesional confluence,that were non-painful,without involvement of the palms and soles of the feet but with a tendency to progression in a generalized manner.He had multiple emergency room visits and poor response to antihistamines and systemic corticosteroids.Imaging studies demonstrated nodules in the lower lingula segment,at the level of the greater fissure and in the anterior contour of the left anterior basal segment associated with parahiliar adenopathies in the absence of findings suggestive of infectious or autoimmune etiology.Segmental lobectomy was performed by thoracoscopy with resection of a lung nodule in the lingula and biopsy of the para-aortic mediastinal ganglion.The histopathological report showed the presence of poorly differentiated invasive adenocarcinoma with a solid morphological and acinar pattern with immunohistochemical description of lung tissue that expresses strong positive and diffuse reaction for thyroid transcription factor 1(TTF-1)with negativity to P40 for a histopathological diagnosis of

关 键 词：URTICARIA Lung adenocarcinoma Undifferentiated carcinoma Paraneoplastic syndromes Thyroid nuclear factor 1 Case report 

分 类 号：R734.2[医药卫生—肿瘤] R758.24[医药卫生—临床医学]