Assessment of the forensic application of 50 Y-STR markers in a large pedigree  

作　　者：Yi Ye Yuran An Yiwen Yang Hao Wu Yuzi Zheng Linchuan Liao 

机构地区：[1]West China School of Basic Medical Sciences&Forensic Medicine,Sichuan University,Chengdu,China [2]Criminal Technology Department,Liupanshui Public Security Bureau,Guizhou,China

出　　处：《Forensic Sciences Research》2022年第2期207-210,共4页法庭科学研究（英文）

基　　金：This work was supported by the National Natural Science Foundation of China[grant number 81401557];This study was funded by ICH-GCP Standardization Construction and Innovation of GCP System[grant number 2018ZX09201018-020].

摘　　要：Short tandem repeats on the Y chromosome(Y-STRs),characterized by paternal inheritance,are valuable in forensic practice.Notably,the potential application of Y-STRs in pedigrees should be drawn upon,especially in China’s surname-concentrated natural villages.The study focused on 50 Y-STRs,including 13 rapidly mutating(RM)Y-STRs that largely constitute the current Y-STR commercial kits,and determined the differences in these Y-STRs between branches in a large pedigree and the discriminatory power of these haplotypes in different units for male relatives.As indicated in the results,14 inconsistencies were observed at 9 Y-STRs between 10 father-son pairs.In addition,these 50 Y-STR haplotypes discriminated 10 out of 47 father-son pairs,106 of 148 cousin pairs,70 of 119 uncle-nephew pairs,17 of 39 brother pairs,and 14 out of 33 grandfather-grandson pairs in a large pedigree.The RM Y-STR set is able to differentiate close male relatives in a large pedigree.

关 键 词：Forensic sciences forensic genetics Y-STR HAPLOTYPE rapid mutation PEDIGREE 

分 类 号：D919[医药卫生—法医学]