Neuropeptide Y and melanocortin receptors in fish:regulators of energy homeostasis  

作　　者：Zhi-Shuai Hou Hai-Shen Wen 

机构地区：[1]Key Laboratory of Mariculture(Ocean University of China),Ministry of Education(KLMME),Fisheries College,Ocean University of China,Qingdao,266003,China

出　　处：《Marine Life Science & Technology》2022年第1期42-51,共10页海洋生命科学与技术（英文）

基　　金：supported by grants from Blue Granary Science and Technology Innovation[2019YFD0901000].

摘　　要：Energy homeostasis,which refers to the physiological processes that the energy intake is exquisitely coordinated with energy expenditure,is critical for survival.Therefore,multiple and complex mechanisms have been involved in the regulation of energy homeostasis.The central melanocortin system plays an important role in modulating energy homeostasis.This system includes the orexigenic neurons,expressing neuropeptide Y/Agouti-related protein(NPY/AgRP),and the anorexigenic neurons expressing proopiomelanocortin(POMC).The downstream receptors of NPY,AgRP and post-translational products of POMC are G protein-coupled receptors(GPCRs).This review summarizes the compelling evidence demonstrating that NPY and melanocortin receptors are involved in energy homeostasis.Subsequently,the comparative studies on physiology and pharmacology of NPY and melanocortin receptors in humans,rodents and teleosts are summarized.Also,we provide a strategy demonstrating the potential application of the new ligands and/or specific variants of melanocortin system in aquaculture.

关 键 词：Energy homeostasis Neuropeptide Y receptors Melanocortin receptors GPCRS Fish(Teleost) 

分 类 号：Q95[生物学—动物学]