The role of bacterial signaling networks in antibiotics response and resistance regulation  

作　　者：Yuying Li Tao Feng Yan Wang 

机构地区：[1]College of Marine Life Sciences,Ocean University of China,Qingdao,266003,China [2]Institute of Evolution and Marine Biodiversity,Ocean University of China,Qingdao,266003,China [3]Laboratory for Marine Ecology and Environmental Science,National Laboratory for Marine Science and Technology(Qingdao),Qingdao,266071,China

出　　处：《Marine Life Science & Technology》2022年第2期163-178,共16页海洋生命科学与技术（英文）

基　　金：supported by the Marine S&T Fund of Shandong Province for the Pilot National Laboratory for Marine Science and Technology(Qingdao)(No.2018SDKJ0406-4);the National Natural Science Foundation of China(No.42176108,31870023);the Fundamental Research Funds for the Central Universities(No.201941009);the Young Taishan Scholars Program of Shandong Province(No.tsqn202103029).

摘　　要：Excessive use of antibiotics poses a threat to public health and the environment.In ecosystems,such as the marine environment,antibiotic contamination has led to an increase in bacterial resistance.Therefore,the study of bacterial response to antibiotics and the regulation of resistance formation have become an important research field.Traditionally,the processes related to antibiotic responses and resistance regulation have mainly included the activation of efflux pumps,mutation of antibiotic targets,production of biofilms,and production of inactivated or passivation enzymes.In recent years,studies have shown that bacterial signaling networks can affect antibiotic responses and resistance regulation.Signaling systems mostly alter resistance by regulating biofilms,efflux pumps,and mobile genetic elements.Here we provide an overview of how bacterial intraspecific and interspecific signaling networks affect the response to environmental antibiotics.In doing so,this review provides theoretical support for inhibiting bacterial antibiotic resistance and alleviating health and ecological problems caused by antibiotic contamination.

关 键 词：Bacterial antibiotic resistance AHL AI-2 AIP INDOLE DSF 

分 类 号：X55[环境科学与工程—环境工程]