p-AKT-mTOR-p70S6K信号通路蛋白与卵巢癌化疗耐药相关性的研究  

Study on the correlation between p-AKT-mTOR-p70S6K signaling pathway protein and chemotherapy resistance in ovarian cancer

作　　者：刘文涓 叶孜渊 曹兰琴[2] LIU Wenjuan;YE Ziyuan;CAO Lanqin(General Hospital of Pingxiang Mining Group Co.,Ltd.,Pingxiang 337000,China;Department of Obstetrics and Gynecology,Xiangya Hospital Central South University,Changsha 410008,China)

机构地区：[1]萍乡矿业集团有限公司总医院,江西萍乡337000 [2]中南大学湘雅医院妇产科,湖南长沙410008

出　　处：《中国现代医生》2022年第17期84-86,90,共4页China Modern Doctor

基　　金：江西省卫生健康委科技计划项目(202140440)。

摘　　要：目的 探讨p-AKT-mTOR-p70S6K信号通路蛋白与卵巢癌化疗耐药相关性。方法 选取2007年2月~2014年5月中南大学湘雅医院收治的卵巢癌患者43例,其中18例患者为耐药组,25例患者为敏感组,对43例患者均实施免疫组化方法检测,对患者p-AKT蛋白、mTOR蛋白、p70S6K蛋白在两组患者中的表达量情况进行观察。结果 p-AKT蛋白、mTOR蛋白、p70S6K蛋白在卵巢癌化疗耐药组织中具有明显较高的阳性表达率,差异有统计学意义(P<0.05)。结论 p-AKT-mTOR-p70S6K信号通路中p-AKT蛋白、mTOR蛋白、p70S6K蛋白在卵巢癌化疗耐药组织中具有较高的阳性表达率,具有较高的临床推广价值。Objective To explore the correlation between p-AKT-mTOR-p70S6K signaling pathway protein and chemotherapy resistance in ovarian cancer. Methods A total of 43 ovarian cancer patients who were admitted to Xiangya Hospital Central South University from February 2007 to May 2014 were selected. Among them, 18 patients were in the drug-resistant group, 25 patients were in the drug-sensitive group. Immunohistochemical methods were performed in all 43 patients. The expression levels of p-AKT protein, mTOR protein, and p70S6K protein in the two groups of patients were observed. Results The positive expression rates of p-AKT protein, mTOR protein, and p70S6K protein in ovarian cancer chemotherapy-resistant tissues were significantly higher than those in sensitive tissues, and the difference was statistically significant(P<0.05). Conclusion In the p-AKT-mTOR-p70S6K signaling pathway, the positive expression rates of p-AKT protein, mTOR protein, and p70S6K protein in ovarian cancer chemotherapy-resistant tissues are significantly higher, which can be used as clinical markers to predict ovarian cancer chemotherapy resistance and have high clinical promotion value.

关 键 词：卵巢癌 化疗 耐药 p-AKT蛋白 mTOR蛋白 p70S6K蛋白 

分 类 号：R737.3[医药卫生—肿瘤]