80例胆道感染患者结石成分及感染菌群临床研究  

Clinical study on stone composition and infection flora in 80 patients with biliary tract infection

作　　者：陈杰 石秀全 黄敬宇 朱杰 刘玉龙 CHEN Jie;SHI Xiu-quan;HUANG Jing-yu(The People's Hospital of Yingshang,Fuyang 236000,Anhui)

机构地区：[1]颍上县人民医院,安徽阜阳236000

出　　处：《安徽医专学报》2022年第3期95-97,共3页Journal of Anhui Medical College

基　　金：2019年度阜阳市卫健委科研课题(FY-2019-094)。

摘　　要：目的:对颍北、颍南地区胆石症伴胆道感染患者进行胆汁培养、细菌分布及药敏统计分析,为临床用药提供可靠依据。方法:选取医院2019年6月-2020年12月收治的患者,患者行腹腔镜下胆总管切开取石术(或开腹胆总管切开取石术),术中抽取胆汁标本,进行细菌培养及药敏分析,随机选取培养结果为阳性的样本80例,颍北、颍南每组40例,分析胆汁培养结果和临床数据。结果:其中革兰阴性菌共检出66株,革兰阳性菌14株。在阴性菌中,大多数对头孢他啶、头孢曲松较敏感,在阳性菌中,大多数对左氧氟沙星、环丙沙星敏感。结论:颍北、颍南地区胆道感染患者以大肠埃希菌为主,头孢他啶或头孢西丁疗效较好,两地区间差异不明显,治疗可优先选用三代抗生素。Objective:To provide data and reliable references for clinical drug use through analyzing the bile culture,bacterial distribution and drug sensitivity statistics from patients with cholelithiasis and biliary tract infection in Yingbei and Yingnan.Methods:Patients underwent laparoscopic choledocholithotomy(or open choledocholithotomy)in the hospital from June 2019 to December 2020 were selected.The bile samples were extracted during their operation for bacterial culture and drug sensitivity analysis.And then 80 samples with positive culture results were randomly selected and divided into two groups with 40 in each to analyze their bile culture results and clinical data.Results:66 gram-negative bacteria and 14 gram-positive bacteria were detected.Among the negative bacteria,most were more sensitive to ceftazidime and ceftriaxone and among the positive bacteria,most were sensitive to levofloxacin and ciprofloxacin.Conclusion:Patients in Yingbei and Yingnan areas are mainly suffering from Escherichia coli.Ceftazidime or cefoxitin has better curative effects and the difference between the two areas is not obvious.Third-generation antibiotics are preferred for treatment.

关 键 词：胆总管结石 胆道感染 药敏实验 耐药性 

分 类 号：R575.7[医药卫生—消化系统]