丁螺环酮联合帕罗西汀在焦虑症治疗中的效果观察  

Effect observation of buspirone combined with paroxetine in the treatment of anxiety disorders

作　　者：岳佳 YUE Jia(Shenyang Mental Health Center,Shenyang 110168,China)

机构地区：[1]沈阳市精神卫生中心,110168

出　　处：《中国现代药物应用》2022年第10期162-164,共3页Chinese Journal of Modern Drug Application

摘　　要：目的 分析丁螺环酮联合帕罗西汀在焦虑症治疗中的效果。方法 240例焦虑症患者作为研究对象,根据用药方案不同分为对照组以及观察组,每组120例。观察组患者应用丁螺环酮联合帕罗西汀治疗,对照组患者单用帕罗西汀治疗。对比两组患者治疗前后的副反应量表(TESS)评分和汉密尔顿焦虑量表(HAMA)评分以及治疗效果。结果 治疗前,两组患者HAMA评分对比差异无统计学意义(P>0.05);治疗后第1、2、4、8周,观察组患者HAMA评分分别为(15.32±8.16)、(10.26±4.15)、(3.98±2.56)、(2.06±1.91)分,均显著低于对照组的(18.82±8.36)、(11.92±4.62)、(6.25±3.15)、(4.45±2.93)分,差异具有统计学意义(P<0.05);两组患者治疗后第1、2、4、8周的TESS评分比较,差异均无统计学意义(P>0.05)。观察组患者的治疗总有效率为96.67%,明显高于对照组的78.33%,差异具有统计学意义(P<0.05)。结论 焦虑症患者应用丁螺环酮联合帕罗西汀治疗的效果显著,值得进一步在临床内推广和应用。Objective To analyze the effect of buspirone combined with paroxetine in the treatment of anxiety disorders. Methods A total of 240 patients with anxiety disorders were selected as the research subjects.According to different drug regimens, they were divided into control group and observation group, with 120 cases in each group. Patients in the observation group were treated with buspirone combined with paroxetine, and patients in the control group were treated with paroxetine alone. The treatment emergent symptom scale(TESS)score and Hamilton anxiety scale(HAMA) score before and after treatment, and therapeutic effects were compared between the two groups. Results Before treatment, there was no statistically significant difference in HAMA score between the two groups(P>0.05). At 1, 2, 4 and 8 weeks of treatment, the HAMA scores of the observation group were(15.32±8.16),(10.26±4.15),(3.98±2.56) and(2.06±1.91) points, which were significantly lower than(18.82±8.36),(11.92±4.62),(6.25±3.15) and(4.45±2.93) points of the control group, and the differences were statistically significant(P<0.05). At 1, 2, 4 and 8 weeks of treatment, there was no statistically significant difference in TESS score between the two groups(P>0.05). The total effective rate of treatment of the observation group was 96.67%, which was obviously higher than 78.33% of the control group, and the difference was statistically significant(P<0.05). Conclusion Buspirone combined with paroxetine has significant effect in the treatment of anxiety disorders, and is worthy of further clinical promotion and application.

关 键 词：丁螺环酮 帕罗西汀 焦虑症 汉密尔顿焦虑量表 副反应量表 

分 类 号：R749.72[医药卫生—神经病学与精神病学]