不同PPI组成的四联疗法对Hp阳性消化性溃疡患者的临床疗效观察  

Clinical Observation of Quadruple Therapy Composed of Different PPIs on Patients with Hp Positive Peptic Ulcer

作　　者：田晔 TIAN Ye(Department of Gastroenterology,Yankuang New Journey General Hospital,Zoucheng 273500,China)

机构地区：[1]兖矿新里程总医院消化内二科,山东邹城273500

出　　处：《中国医药指南》2022年第18期37-40,共4页Guide of China Medicine

摘　　要：目的探讨不同PPI组成的含铋剂四联疗法对Hp阳性消化性溃疡患者的临床疗效。方法为比较奥美拉唑和雷贝拉唑与组成的含铋剂四联疗法对治疗Hp阳性消化性溃疡的治疗效果,以我院于2019年8月至2020年8月收治的200例患Hp阳性消化性溃疡疾病的患者作为研究对象,将其随机分为100例对照组和100例试验组,分别对其施以奥美拉唑肠溶片联合丽珠维三联2周、继续服用奥美拉唑2周,雷贝拉唑钠肠溶片联合丽珠维三联2周、继续服用雷贝拉唑2周。比较两组治疗前后临床症状改善情况、Hp根除率、溃疡愈合率,不良反应发生率、治疗满意度等。结果治疗前,两组患者的症状评分无明显差异(P>0.05);治疗结束后,两组患者的症状评分都有明显改善(P<0.05)。试验组患者症状评分明显比对照组低,说明试验组患者症状评分改善更明显(P<0.05)。试验组患者的Hp根除率为95%,明显比对照组患者的Hp根除率(75%)高(P<0.05,χ_(2)=15.6863)。胃镜下,两组患者溃疡都有明显愈合,试验组患者总有效率为94%,明显比对照组痊愈率(78%)高(P<0.05,χ_(2)=10.6312)。两组患者主要发生的不良反应有四种:大便发黑、恶心、头痛以及腹泻等,两组患者发生不良反应的情况无差异(P>0.05),差异无统计学意义。试验组患者的治疗满意度为93%,明显比对照组患者的治疗满意度(77%)高(P<0.05,χ_(2)=10.0392)。结论本研究表明治疗Hp阳性DU过程中,雷贝拉唑药物能够使患者的临床症状明显得以改善、达到根除Hp的理想效果、促进溃疡的愈合,值得在临床上加以广泛推广。Objective To investigate the clinical efficacy of bismuth containing quadruple therapy composed of different PPIs in patients with Hp positive peptic ulcer.Methods In order to compare the therapeutic effect of omeprazole and rabeprazole combined with bismuth containing agent in the treatment of Hp positive peptic ulcer,200 patients with Hp positive peptic ulcer in our hospital from August 2019 to August 2020 were randomly divided into 100 control group and 100 experimental group,they were given omeprazole enteric coated tablets combined with Lizhuwei triple for 2 weeks,omeprazole for 2 weeks,rabeprazole sodium enteric coated tablets combined with Lizhuwei triple for 2 weeks,and rabeprazole for 2 weeks.The improvement of clinical symptoms,Hp eradication rate,ulcer healing rate,incidence of adverse reactions and treatment satisfaction were compared between the two groups before and after treatment.Results Before treatment,there was no significant difference in symptom scores between the two groups(P>0.05);After treatment,the symptom scores of patients in both groups were significantly improved(P<0.05).The symptom scores of patients in the experimental group were significantly lower than those in the control group,indicating that the symptom scores of patients in the experimental group were significantly improved(P<0.05).The Hp eradication rate of patients in the experimental group was 95%,which was significantly higher than that of patients in the control group(75%)(P<0.05,χ_(2)=15.6863).Under gastroscope,the ulcers of patients in both groups healed significantly.The total effective rate of patients in the experimental group was 94%,which was significantly higher than that in the control group(78%)(P<0.05,χ_(2)=10.6312).There were four main adverse reactions in the two groups:black stool,nausea,headache and diarrhea.There was no difference between the two groups(P>0.05).The treatment satisfaction of patients in the experimental group was 93%,which was significantly higher than that of patients in the control grou

关 键 词：PPI 四联疗法 HP阳性 消化性溃疡 临床疗效 

分 类 号：R573.1[医药卫生—消化系统]