颈动脉粥样硬化与脑梗死患者认知功能障碍的相关性分析  

Correlation analysis of carotid atherosclerosis and cognitive dysfunction in patients with cerebral infarction

作　　者：陈丽红[1] 余国亮[2] 潘小红 王凤[3] CHEN Lihong;YU Guoliang;PAN Xiaohong;WANG Feng(Department of Emergency Medicine,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai 317000,China;Department of Critical Care,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai 317000,China;Department of Neurology,Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University,Linhai 317000,China)

机构地区：[1]浙江省台州医院急诊科,浙江临海317000 [2]浙江省台州医院重症医学科,浙江台州317000 [3]浙江省台州医院神经内科,浙江临海317000

出　　处：《中国现代医生》2022年第18期129-132,共4页China Modern Doctor

基　　金：浙江省卫生健康科技计划项目(2021RC141)。

摘　　要：目的探讨颈动脉粥样硬化与脑梗死患者认知功能障碍的关系。方法选择2020年1月~2021年3月于浙江省台州医院诊断治疗的脑梗死患者60例为研究对象。根据患者治疗后3个月MMSE评分结果分为认知功能障碍组(观察组)33例,认知功能正常组(对照组)27例。比较两组的颈动脉狭窄程度、IMT、斑块面积、斑块形态,分析颈动脉狭窄程度、IMT、斑块面积、斑块形态与MMSE评分的相关性。结果观察组颈动脉内膜中层厚度、斑块面积显著高于对照组,差异有统计学意义(P<0.05);两组斑块形态分布比较,差异无统计学意义(P>0.05)。观察组颈动脉狭窄程度显著高于对照组,差异有统计学意义(P<0.05);观察组重度狭窄的例数要高于对照组,秩和检验结果显示,两组不同狭窄程度的分布存在差异(P<0.05)。颈动脉内膜中层厚度与MMSE评分呈显著负相关(r=-0.881)。斑块面积与MMSE评分呈显著负相关(r=-0.890)。颈动脉狭窄程度与MMSE评分呈显著负相关(r=-0.903)。结论认知功能障碍是脑梗死后的常见并发症,患者颈动脉粥样硬化斑块的面积、颈动脉IMT、颈动脉狭窄程度与认知功能障碍有显著的相关性。Objective To investigate the relationship between carotid atherosclerosis and cognitive dysfunction in patients with cerebral infarction.Methods Sixty patients with cerebral infarction diagnosed and treated in the hospital from January 2020 to March 2021 were selected as the research objects.According to the results of the MMSE score,three months after treatment,the patients were divided into the cognitive dysfunction group(the observation group,n=33)and the normal cognitive function group(the control group,n=27).The degree of carotid artery stenosis,IMT,plaque area,and plaque morphology were compared between the two groups.The correlation between the degree of carotid artery stenosis,IMT,plaque area,plaque shape,and MMSE score was compared analyzed.Results The carotid artery intima-media thickness and plaque area of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in plaque morphological distribution between the two groups(P>0.05).The degree of carotid artery stenosis in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The number of severe stenosis in the observation group was higher than that in the control group.The results of the rank-sum test showed that there was a difference in the distribution of different degrees of stenosis between the two groups(P<0.05).The carotid artery intima-media thickness was significantly negatively correlated with the MMSE score(r=-0.881).There was a significant negative correlation between plaque area and MMSE score(r=-0.890).The degree of carotid artery stenosis was significantly negatively correlated with the MMSE score(r=-0.903).Conclusion Cognitive dysfunction is a common complication after cerebral infarction.The area of carotid atherosclerotic plaque,carotid artery IMT,and the degree of carotid artery stenosis are significantly correlated with cogniti

关 键 词：颈动脉粥样硬化 狭窄程度 脑梗死 认知功能 

分 类 号：R743.3[医药卫生—神经病学与精神病学]