积极参与国际高质量临床试验提高中国结直肠外科临床研究水平  

Actively participate in international high-quality clinical trials for improving the research level of colorectal surgery in China

作　　者：姚宏伟[1] 杨正阳 高加勒 刘怡杉 Stefan van Oostendorp Annabel van Lieshout Jurriaan Tuynman Jaap Bonjer 张忠涛[1] Yao Hongwei;Yang Zhengyang;Gao Jiale;Liu Yishan;Stefan van Oostendorp;Annabel van Lieshout;Jurriaan Tuynman;Jaap Bonjer;Zhang Zhongtao(Department of General Surgery,Beijing Friendship Hospital,National Clinical Research Center for Digestive Diseases,Beijing Key Laboratory of Cancer Invasion and Metastasis Research,Clinical Practice and Research Center for Colorectal Cancer,Capital Medical University,Beijing 100050,China;Department of Surgery,Department of Colorectal Surgery,Amsterdam University Medical Centre,Amsterdam 1012,Netherlands)

机构地区：[1]首都医科大学附属北京友谊医院普通外科,国家消化系统疾病临床医学研究中心,肿瘤侵袭和转移机制研究北京市重点实验室,首都医科大学结直肠肿瘤临床诊疗与研究中心,北京100050 [2]阿姆斯特丹大学医学中心外科和结直肠外科,阿姆斯特丹1012

出　　处：《中华消化外科杂志》2022年第6期749-752,共4页Chinese Journal of Digestive Surgery

基　　金：国家科技支撑计划课题(2015BAI13B09);国家重点研发计划(2017YFC0110904);北京市医院管理局临床医学发展专项基金(ZYLX201504);首都医科大学结直肠肿瘤临床诊疗与研究中心基金项目(1192070313);首都医科大学附属北京友谊医院科研启动基金(YYQDKT2016-5)。

摘　　要：中国的结直肠癌患者数量一直位居世界前列。然而,中国的国际性结直肠癌诊断与治疗指南或高级别循证医学研究证据十分罕见。经肛全直肠系膜切除术(taTME)是近年发展起来的结直肠外科领域新手术方式,目前国际上taTME相关临床实践一直与临床研究同步开展。笔者结合参加国际结直肠外科研究领域顶级临床研究(COLOR系列前瞻性研究)的经验,介绍COLORⅢ研究在中国的组织实施情况,希望COLOR系列研究成为高质量外科临床研究领域的范例,进而提高中国结直肠外科临床研究水平。The number of colorectal cancer patients in China ranks the top in the world,but there are few international guidelines for the diagnosis and treatment of colorectal cancer formulated by Chinese,nor high-level evidence-based medicine research of colorectal cancer from China.Transanal total mesorectal excision(taTME)is a new technology in the field of colorectal surgery in recent years.At present,clinical practice related to taTME has been carried out simul-taneously with clinical researches in the world.Based on the experience of participating in the top clinical trials in the field of international colorectal surgery,like the COLOR series prospective research,the authors introduce the organization and implementation of COLORⅢresearch in China.It is hoped that the COLOR series trials will become an example in the field of high-quality surgical clinical research,so as to improve the clinical research level of colorectal surgery in China.

关 键 词：直肠肿瘤 结直肠外科 经肛全直肠系膜切除术 临床研究 国际合作 

分 类 号：R735.34[医药卫生—肿瘤]