埃索美拉唑治疗消化性溃疡患者的临床效果观察  

Clinical Effect Observation of Esomeprazole in the Treatment of Peptic Ulcer

作　　者：王东芳[1] Wang Dongfang(Zhengzhou First People's Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第一人民医院,河南郑州450000

出　　处：《哈尔滨医药》2022年第2期11-13,共3页Harbin Medical Journal

摘　　要：目的探讨埃索美拉唑治疗消化性溃疡患者的临床疗效及对血清炎症因子和胃肠激素水平的影响。方法以80例消化性溃疡患者为对象,随机分为对照组和观察组,每组各40例,对照组采用奥美拉唑四联疗法治疗,观察组采用埃索美拉唑四联疗法治疗,比较两组临床疗效,观察治疗前后两组血清炎症因子[白介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)]、胃肠激素指标[胃泌素(GAS)、血浆胃动素(MOT)、生长抑素(SS)]、Hp清除率和药物安全性。结果治疗后观察组总有效率95.00%高于对照组的87.50%(P>0.05);与治疗前相较,治疗后两组IL-8、TNF-α、GAS、MOT显著下降,且观察组显著低于对照组,治疗后观察组和对照组SS明显增高,但观察组显著高于对照组(P<0.05);观察组治疗后Hp清除率较对照组显著高(P<0.05),两组不良反应总发生率比较差异无统计学意义(P>0.05)。结论埃索美拉唑治疗消化性溃疡患者的临床疗效明确,在降低患者炎症因子和调节血清胃肠激素水平方面有明显的优势,并且可有效提高Hp清除率,有一定药物安全性。Objective This study was aimed to investigate the clinical effects of esomeprazole in the treatment of peptic ulcer and influence on serum levels of inflammatory factors and gastrointestinal hormones.Methods 80 patients with peptic ulcer were enrolled in this study and randomly assigned to receive omegaprazole quadruple therapy(control group,40 cases)or esomeprazole quadruple therapy(observation group,40 cases).Clinical effects of the two groups were compared.Meanwhile,serum inflammatory factors[interleukin-8(IL-8),tumor necrosis factor-α(TNF-α)],gastrointestinal hormones[gastrin(GAS),plasma motilin(MOT),somatostatin(SS)],Hp clearance rate and drug safety were observed.Results After treatment,the total response rate in the observation group was 95.00%,higher than 87.50%in the control group(P>0.05).After treatment,IL-8,TNF-α,GAS and MOT significantly decreased,while SS significantly increased in the 2 groups.Besides,IL-8,TNF-α,GAS and MOT were lower,and SS was significantly higher in the observation group than in the control group(P<0.05).The Hp clearance rate was significantly higher in the observation group than in the control group after treatment(P<0.05).No significant difference was found between the 2 groups in the total incidence of adverse drug reactions(P>0.05).Conclusion The clinical effect of esomeprazole in the treatment of patients with peptic ulcer is definite.It has significant advantages in lower inflammatory factor levels and regulating serum gastrointestinal hormones.Besides,it can effectively improve the Hp clearance rate,with certain safety.

关 键 词：消化性溃疡 埃索美拉唑 临床疗效 胃肠激素 

分 类 号：R573.1[医药卫生—消化系统]