趋化因子CXCL10作为肝硬化生物标志物的意义  

Significance of CXCL10 as a Biomarker of Liver Cirrhosis

作　　者：李思琪 邰文琳[1] LI Siqi;TAI Wenlin(Dept.of Clinical Laboratory,The 2nd Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

机构地区：[1]昆明医科大学第二附属医院检验科,云南昆明650101

出　　处：《昆明医科大学学报》2022年第7期55-61,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(82060385)。

摘　　要：目的探讨CXCL10作为一种肝硬化无创生物标志物的潜力及其在肝纤维化进展中的机制。方法收集2021年3~8月期间昆明医科大学第二附属医院肝硬化患者(n=64)和健康体检者(n=64)EDTAK2抗凝管外周血标本,严格记录患者的基本信息和实验室检查结果。ELISA检测血浆中CXCL10浓度。分析CXCL10表达水平与生化检验结果的关系。用ROC曲线分析血浆CXCL10水平对肝硬化的预测价值。结果肝硬化患者血浆CXCL10浓度显著高于健康体检者,差异有统计学意义(P<0.0001)。肝硬化患者血浆CXCL10水平与检验结果如ALT、AST、PT、APTT、DD成正相关关系(P<0.05)。CXCL10的ROC曲线下面积为0.8264,具有较好的诊断效能。结论CXCL10可作为肝硬化的一种无创生物标志物,也是肝硬化潜在的治疗靶点。Objective To investigate the potential of CXCL10 as a noninvasive biomarker of liver cirrhosis and its mechanism in the progression of liver fibrosis.Methods Peripheral blood samples of EDTA-K2 anticoagulant tubes were collected from cirrhotic patients(n=64)and healthy subjects(n=64)in the Second Affiliated Hospital of Kunming Medical University from March to August 2021,and the basic information and laboratory examination results of the patients were strictly recorded.CXCL10 concentration in plasma was determined by ELISA.The relationship between CXCL10 expression level and biochemical test results was analyzed.ROC curve was used to analyze the predictive value of plasma CXCL10 levels for cirrhosis.Results The plasma CXCL10 concentration in patients with cirrhosis was significantly higher than that in healthy subjects,and the difference was statistically significant(P<0.0001).Plasma CXCL10 levels were positively correlated with ALT,AST,PT,APTT and DD in patients with cirrhosis(P<0.05).The area under ROC curve of CXCL10 is 0.8264,which has good diagnostic performance.Conclusion CXCL10 can be used as a non-invasive biomarker and a potential therapeutic target for liver cirrhosis.

关 键 词：肝纤维化 CXCL10 肝硬化 

分 类 号：R575.1[医药卫生—消化系统]