胃癌组织中LINC00152、UBE2Q1的表达及意义  

Expression and Significance of LINC00152 and UBE2Q1 in Gastric Cancer

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作  者:叶雅丽[1] 阮荣华[1] 蔡莎莎[1] 段达荣[1] 符竣惠[2] YE Ya-li;RUAN Rong-hua;CAI Sha-sha;DUAN Da-rong;FU Jun-hui(Department of Laboratory Medicine,Taizhou First People’s Hospital,Taizhou 318020,Zhejiang,China;Department of General Surgery,Taizhou First People’s Hospital,Taizhou 318020,Zhejiang,China)

机构地区:[1]台州市第一人民医院检验科,浙江台州318020 [2]台州市第一人民医院普外科,浙江台州318020

出  处:《医学信息》2022年第13期94-96,共3页Journal of Medical Information

基  金:浙江省台州市科学技术局项目(编号:1801ky67、21ywa45)。

摘  要:目的研究胃癌组织中长链非编码RNA LINC00152、泛素接合酶E2Q1(UBE2Q1)的表达,并探讨其临床意义。方法选取2017年1月-2021年3月台州市第一人民医院首次诊断胃癌患者79例,采用实时荧光定量PCR(RT-qPCR)方法检测胃癌患者癌组织和癌旁组织中LINC00152和UBE2Q1的表达,评估LINC00152和UBE2Q1在胃癌患者不同组织中的差异表达及其与临床病理因素的关系。结果胃癌组织中LINC00152、UBE2Q1表达高于癌旁组织,差异有统计学意义(P<0.05);LINC00152表达与分化程度有关,UBE2Q1表达与TNM分期、转移有关(P<0.05)。结论LINC00152和UBE2Q1在胃癌组织中高表达,有望成为胃癌诊断的生物标志物和肿瘤治疗的靶点。Objective To study the expression of long-chain noncoding RNALINC00152 and ubiquitin-conjugating enzyme e2q1(UBE2Q1)in gastric cancer and its clinical significance.Methods A total of 79 patients with gastric cancer first diagnosed in Taizhou First People’s Hospital from January2017 to March 2021 were selected.The expressions of LINC00152 and UBE2Q1 in cancer tissues and adjacent tissues of gastric cancer patients were detected by real-time fluorescence quantitative PCR(RT-qPCR).The differential expressions of LINC00152 and UBE2Q1 in different tissues of gastric cancer patients and their relationship with clinicopathological factors were evaluated.Results The expression of LINC00152 and UBE2Q1 in gastric cancer tissues was higher than that in adjacent tissues,and the difference was statistically significant(P<0.05).LINC00152 expression was related to differentiation degree,and UBE2Q1 expression was related to TNM staging and metastasis(P<0.05).Conclusion LINC00152 and UBE2Q1are highly expressed in gastric cancer,which is expected to be biomarkers for the diagnosis of gastric cancer and targets for tumor therapy.

关 键 词:胃癌 LINC00152 UBE2Q1 实时荧光定量PCR 

分 类 号:R735.2[医药卫生—肿瘤]

 

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