中老年人非酒精性脂肪肝与不同部位骨密度的相关性分析  

Correlation analysis of non-alcoholic fatty liver disease and bone density in different sites in middle-aged and elderly people

作　　者：杜展 罗杰 梁东莉 李碧彩 陈明发 刘萍 魏丽萍 DU Zhan;LUO Jie;LIANG Dongli;LI Bicai;CHEN Mingfa;LIU Ping;WEI Liping(Department of Medical Examination,the Third Affiliated Hospital of Shenzhen University,Shenzhen Luohu People's Hospital,Shenzhen,Guangdong 518000,China;Department of Hepatology,the Third Affiliated Hospital of Shenzhen University,Shenzhen Luohu People's Hospital,Shenzhen,Guangdong 518000,China)

机构地区：[1]深圳大学第三附属医院深圳市罗湖区人民医院体检科,广东深圳518000 [2]深圳大学第三附属医院深圳市罗湖区人民医院肝病科,广东深圳518000

出　　处：《检验医学与临床》2022年第S01期1-4,共4页Laboratory Medicine and Clinic

基　　金：广东省医学科学技术研究基金项目(B2020057);广东省深圳市罗湖区软科学研究计划项目(LX20191307,LX20201108)。

摘　　要：目的评价中老年人非酒精性脂肪肝(NAFLD)与不同检测部位骨密度(BMD)的相关性。方法回顾性研究2019年12月至2021年6月在该院常规体检中老年人,同时进行BMD检测和上腹部超声检查,使用骨密度仪(双能X线)检测患者左髋及腰椎BMD,收集年龄、性别、体质量指数、临床生化指标等资料,采用Logistic回归分析影响骨量减少的因素,Spearman相关性分析临床参数与腰椎、左髋BMD的关系,并进行多元线性回归分析,分别建立回归方程,评估影响腰椎、左髋BMD的相关因素。结果本研究纳入患者339例,男165例,依据彩超诊断脂肪肝结果分为对照组和脂肪肝两组,对照组189例(55.75%),脂肪肝组150例(44.25%);多因素分析提示年龄、脂肪肝是发生骨量减少的危险因素;腰椎BMD(Y1)与年龄、脂肪肝、血糖、AST、ALP呈负相关,与肌酐呈正相关。左髋BMD(Y2)与年龄、脂肪肝呈负相关。结论年龄、是否有脂肪肝是影响中老年人骨量减少的危险因素,腰椎BMD、左髋BMD均与年龄、脂肪肝呈负相关。Objective To evaluate the correlation between nonalcoholic fatty liver disease(NAFLD)and bone mineral density(BMD)at different sites.Methods A retrospective study was conducted on middle-aged and elderly people in the hospital from December 2019 to June 2021,both BMD testing and upper abdominal ultrasound were performed,the left hip and lumbar BMD was detected using a bone densitomeometer(double energy X-line),data on age,sex,body mass index(BMI),and clinical biochemical indicators were collected,Logistic regression was used to analyze the factors affecting the reduced bone mass,Spearman correlation analyzed the relationship between clinical parameters and BMD of lumbar and left hip,Multiple linear regression analysis was also performed,The regression equations were separately established to evaluate related factors affecting BMD in lumbar and left hip.Results In this study,339 patients were included,of whom 165 men.According to the color ultrasound,these are divided into control group and fatty liver guoup.189(55.75%)cases in control group and 150(44.25%)in fatty liver group;multivariate analysis suggested that age and fatty liver were risk factors for reduced bone mass;lumbar BMD(Y1)was negatively associated with age,fatty liver,blood sugar and AST,ALP and positively associated with creatinine.The left hip BMD(Y2)was negatively associated with age and fatty liver.Conclusion Age and fatty liver are risk factors affecting reducing bone mass in middle and elderly people,and lumbar BMD and left hip BMD were negatively associated with age and fatty liver.

关 键 词：非酒精性脂肪肝 骨密度 骨质疏松 

分 类 号：R57[医药卫生—消化系统]