磁共振表观扩散系数直方图和血清CA125有助于评估子宫内膜样腺癌的病理组织学特征  

MRI apparent diffusion coefficient histogram and serum CA125 help to evaluate the histopathological characteristics of endometrial adenocarcinoma

作　　者：王宏睿 李金玲[3] 张强[1] 张克勤 张虎[1,2] WANG Hongrui;LI Jinling;ZHANG Qiang;ZHANG Keqin;ZHANG Hu(Department of Radiology,Binzhou Medical University,Binzhou 256603,China;School of Medical Imaging,Binzhou Medical University,Yantai 264003,China;Department of Clinical Laboratory,Binzhou Medical University,Binzhou 256603,China)

机构地区：[1]滨州医学院附属医院放射科,山东滨州256603 [2]滨州医学院医学影像学院,山东烟台264003 [3]滨州医学院附属医院检验科,山东滨州256603

出　　处：《分子影像学杂志》2022年第4期480-485,共6页Journal of Molecular Imaging

基　　金：山东省大学生创新训练项目(S202110440040)。

摘　　要：目的探究基于子宫内膜样腺癌表观扩散系数(ADC)直方图分析和糖类抗原125(CA125)与组织分化程度、微卫星、Ki-67的相关性。方法搜集68例首诊且经病理证实为子宫内膜样腺癌患者资料。所有患者均行超导核磁共振扫描,用FireVoxel软件在ADC图测得肿瘤感兴趣区的直方图参数。分析子宫内膜样腺癌的直方图参数和CA125与组织分化程度、微卫星、Ki-67的相关性。结果直方图参数、Ki-67差距在不同组织分化程度中均有统计学意义(P<0.05)。直方图参数、Ki-67及CA125均值差距在微卫星稳定组与不稳定组没有统计学意义(P>0.05)。ROC曲线统计计算出P90值对应的曲线下面积最大(0.937)。直方图参数与组织分化程度呈低或中等程度负相关(P<0.05);平均数、最大值、P10、P25、P50、P75、P90、P95与Ki-67呈低等程度负相关(P<0.05)。结论ADC直方图参数和血清CA125有助于评估子宫内膜腺癌的病理组织学特征。Objective To explore the correlation between the whole focus apparent diffusion coefficient(ADC)histogram analysis and CA125 and the degree of differentiation,microsatellite and Ki-67 of endometrioid adenocarcinoma,respectively.Methods Sixty-eight patients with endometrial carcinoma confirmed by preoperative pathology.All patients underwent superconducting MRI scans.The ROIs were drawn by FireVoxel software and histogram analysis was carried out.The correlation between the ADC histogram parameters and CA125 and differentiation,microsatellite and Ki-67 of endometrioid adenocarcinoma were analyzed.Results The ADC histogram parameter and Ki-67 were statistically significant in different tissue differentiation degrees(P<0.05).The ADC histogram parameters,Ki-67 and CA125 differences were not statistically significant between the stable and unstable microsatellite groups(P>0.05).ROC curve analysis showed that P90 achieved the highest AUC of 0.937.Histogram parameters were negatively correlated with the degree of tissue differentiation with low or middle degree.Mean,maximum,P10,P25,P50,P75,P90,P95 and Ki-67 were negatively correlated with low degrees.Conclusion ADC histogram parameters and serum CA125 help to evaluate the histopathological characteristics of endometrial adenocarcinoma.

关 键 词：子宫内膜样腺癌 表观扩散系数 直方图 组织学分级 微卫星 糖类抗原125 

分 类 号：R737.33[医药卫生—肿瘤] R445.2[医药卫生—临床医学]