新型冠状病毒入侵的宿主因子及潜在抗病毒药物研究进展  

Research Progress on the Host Factors Involved in Viral Entry and Potential Antiviral Agents of SARS-CoV-2

作　　者：林聪湄 张浩 卢鑫可 齐璐璐 申屠旭萍 冯华朋 邬丽 LIN Congmei;ZHANG Hao;LU Xinke;QI Lulu;SHENTU Xuping;FENG Huapeng;WU Li(College of Liang Xin,China Jiliang University,Hangzhou 310000,China;College of Life Sciences,China Jiliang University,Hangzhou 310000,China;College of Life Sciences and Medicine,Zhejiang Sci-Tech University,Hangzhou 310000,China)

机构地区：[1]中国计量大学量新学院,杭州310000 [2]中国计量大学生命科学学院,杭州310000 [3]浙江理工大学生命科学与医药学院,杭州310000

出　　处：《病毒学报》2022年第3期714-723,共10页Chinese Journal of Virology

基　　金：浙江省大学生科技创新活动计划资助项目(项目号:2021R409024),题目:过表达ACE2并利用CRISPR/Cas9技术敲除IFITM3基因的疫苗高产细胞株的构建;国家级大学生创新创业训练计划资助项目(项目号:202010356046),题目:双表达人新型冠状病毒受体蛋白ACE2和TMPRSS2的Vero E6疫苗高产细胞株的构建;浙江省自然科学基金(项目号:LQ22C180003)题目:宿主因子S100A4与流感病毒M2互作调控流感病毒复制的分子机制研究。

摘　　要：新型冠状病毒(SARS-CoV-2)是一种新发高传染性的冠状病毒。因其编码有限的病毒蛋白,SARS-CoV-2需要借助多种宿主因子完成其生命周期,而大多数参与其中的宿主因子及作用机理仍不明确。因此,研究参与SARS-CoV-2复制周期的宿主因子及作用机理,将有助于我们对病毒生命周期的认识及寻找抗SARS-CoV-2药物的作用靶点,从而可以帮助人们更加有效地防控新冠疫情。本文归纳了参与SARS-CoV-2复制周期中入侵的宿主因子,对全面理解SARS-CoV-2致病的分子机制、病毒感染的快速诊断及抗病毒新药研发具有重要的意义。Severe acute respiratory syndrome-coronavirus-2(SARS-CoV-2)is a highly infectious pathogen detected in December 2019.Due to its limited protein encoding,SARS-CoV-2 requires several host factors to complete its lifecycle.However,the host factors involved and their mode of action are not clear.Therefore,studying the mechanism of the host factors involved in the SARS-CoV-2 replication cycle can aid understanding of the lifecycle of SARS-CoV-2 and identify the targets of anti-SARS-CoV-2 drugs.This strategy can help to prevent and control coronavirus disease-2019.In this review,we summarize the reported host factors involved in the entry of SARS-CoV-2:this is very important for understanding SARS-CoV-2 pathogenicity,the rapid diagnosis of infection,and developing novel antiviral drugs.

关 键 词：新型冠状病毒 宿主因子 生命周期 入侵 

分 类 号：R373.1[医药卫生—病原生物学]