不同频次无抽搐电休克治疗难治性精神分裂症的临床效果及对PANSS、TESS评分的影响  

Clinical effect of different frequency of modified electric convulsive therapy in the treatment of refractory schizophrenia and the influences on PANSS and TESS scores

作　　者：万发增 金晓忠 WAN Fazeng;JIN Xiaozhong(Lianyungang City Ganyu District Psychiatric Hospital,Lianyungang 222100;the Fourth People's Hospital of Yancheng City,Yancheng 224003,China)

机构地区：[1]连云港市赣榆区精神病医院,江苏连云港222100 [2]盐城市第四人民医院,江苏盐城224003

出　　处：《临床医学研究与实践》2022年第21期42-44,共3页Clinical Research and Practice

摘　　要：目的探究不同频次的无抽搐电休克(MECT)治疗难治性精神分裂症的临床效果及对阳性和阴性症状量表(PANSS)、副反应量表(TESS)评分的影响。方法选择我院2019年1月至2020年7月接受治疗的80例难治性精神分裂症患者作为研究对象,按照MECT治疗频次的不同将其分为观察组(n=40,2次/周)和对照组(n=40,1次/周)。比较两组的治疗效果。结果治疗前及治疗12周后,两组的PANSS评分比较,差异无统计学意义(P>0.05);治疗2、4、6、12周后,两组的PANSS评分均低于治疗前(P<0.05);治疗2、4、6周后,观察组的PANSS评分低于对照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗12周后,两组的治疗总有效率比较,差异无统计学意义(P>0.05)。结论采取MECT治疗难治性精神分裂症患者取得了良好效果,MECT治疗频次为2次/周的效果优于1次/周,但这两种频次的治疗效果和不良反应总发生率无显著差异。Objective To explore the clinical effect of different frequency of modified electric convulsive therapy(MECT)in the treatment of refractory schizophrenia and the influences on positive and negative symptom scale(PANSS)and treatment emergent symptom scale(TESS)scores.Methods A total of 80 patients with refractory schizophrenia who were treated in our hospital from January 2019 to July 2020 were selected as the research objects.The patients were divided into observation group(n=40,2 times/week)and control group(n=40,1 time/week)according to the frequency of MECT treatment.The therapeutic effects of the two groups were compared.Results There was no significant difference in PANSS score between the two groups before treatment and at 12 weeks after treatment(P>0.05);after 2,4,6 and 12 weeks of treatment,the PANSS score of the two groups was lower than that before treatment(P<0.05);after 2,4 and 6 weeks of treatment,the PANSS scores of the observation group was lower than that of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After 12 weeks of treatment,there was no significant difference in the total effective rate of treatment between the two groups(P>0.05).Conclusion MECT has achieved good results in the treatment of refractory schizophrenia.The effect of MECT treatment frequency of 2 times/week is better than that of 1 time/week,but there are no significant difference in the treatment effect and the total incidence of adverse reactions between the two frequencies.

关 键 词：难治性精神分裂症 无抽搐电休克 阳性和阴性症状量表 副反应量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]