支气管动脉灌注化疗联合栓塞治疗肺癌合并咯血疗效分析  

Bronchial arterial infusion embolization for hemoptysis in advanced primary lung cancer

作　　者：李艳春 李晓冰 殷美攀 马耀臻 朱明[2] 刘超[2] 李春霞[2] 李茹娜 刘建刚 吴刚[2] LI Yanchun;LI Xiaobing;YIN Meipan;MA Yaozhen;ZHU Ming;LIU Chao;LI Chunxia;LI Runa;LIU Jiangang;WU Gang(Department of Respiratory and Critical Care Medicine, The 989th Hospital of the Joint Support Force of the Chinese People's Liberation Army, Pingdingshan 467000, China;Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China)

机构地区：[1]中国人民解放军联勤保障部队第九八九医院呼吸与危重症医学科,河南平顶山467000 [2]郑州大学第一附属医院介入科,河南郑州450052

出　　处：《医学影像学杂志》2022年第7期1161-1164,共4页Journal of Medical Imaging

摘　　要：目的探讨支气管动脉灌注化疗联合栓塞治疗肺癌合并咯血的安全性及有效性。方法选取我院2016年6月~2021年10月采用支气管动脉灌注化疗联合栓塞治疗的94例肺癌合并咯血患者的临床及影像资料,评估临床疗效,观察术后不良反应,分析无咯血生存期和总生存期。结果本组肿瘤疗效评估完全缓解(CR)28例(34.6%),部分缓解(PR)41例(50.6%),稳定(SD)9例(11.1%),进展(PD)3例(3.7%),客观缓解率为85.2%,疾病控制率为96.3%。本组患者中位无咯血生存期为9.0月(95%CI:6.87~11.13),中位生存期为10.0月(95%CI:6.83~13.17)。所有不良事件均为1级不良事件。结论支气管动脉灌注化疗联合栓塞治疗肺癌合并咯血安全、有效,可耐受性良好,在临床上是一种可行的姑息性治疗手段。Objective To evaluate the safety and effectiveness of bronchial artery infusion embolization in the treatment of lung cancer with hemoptysis.Methods The clinical and imaging data of 94 lung cancer patients with hemoptysis admitted to our hospital from June 2016 to December 2021 were retrospectively analyzed.Bronchial artery infusion embolization was used for treatment.We evaluated clinical efficacy,observed postoperative adverse reactions,and analyzed hemoptysis-free survival and overall survival.Results The tumor curative effect evaluation after treatment was CR in 28 cases(34.6%),PR in 41(50.6%)cases,SD in 9(11.1%)cases,and PD in 3(3.7%)cases,the objective response rate was 85.2%,and the disease control rate was 96.3%.The median survival time of patients without hemoptysis was 9.0 months(95%CI 6.87~11.13),and the median survival time was 10.0 months(95%CI 6.83~13.17).All adverse events were grade 1 adverse events.Conclusion Bronchial arterial infusion embolization is safe,effective,and well tolerable in the treatment of lung cancer with hemoptysis.It is a feasible palliative treatment in clinical practice.

关 键 词：肺癌 咯血 灌注化疗 栓塞 介入性放射学 

分 类 号：R734.2[医药卫生—肿瘤] R815[医药卫生—临床医学]