MOG抗体病的临床及影像学研究现状  

Current status of clinical and imageology on MOG antibody disease

作　　者：孟义然 黄靖[1,2] 卢洁 MENG YiRan;HUANG Jing;LU Jie(Department of Radiology and Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing 100053, China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]磁共振成像脑信息学,北京市重点实验室,北京100053

出　　处：《医学影像学杂志》2022年第7期1223-1226,共4页Journal of Medical Imaging

基　　金：北京市医院管理局“登峰”计划专项经费资助项目(编号:DFL20180802)。

摘　　要：髓鞘少突胶质细胞糖蛋白(myelin oligodendrocyte glycoprotein,MOG)抗体病是一种由MOG介导的中枢神经系统炎性脱髓鞘疾病,MOG抗体病主要临床表现为双侧同时受累的视神经炎、横贯性脊髓炎和急性播散性脑炎。MOG抗体病在免疫病理、临床特征和影像学特征与多发性硬化(multiple sclerosis,MS)和视神经脊髓炎谱系疾病(neuromyelitis optical disease spectrum,NMOSD)有所区别,该疾病现在认为是一种独立的疾病。本文就MOG抗体病的临床及影像学特征研究现状作一综述。MOG antibody disease is an inflammatory demyelinating disease of the central nervous system mediated by myelin oligodendrocyte glycoprotein(MOG).The main clinical manifestations were bilateral involvement of optic neuritis,trans-myelitis and acute disseminated encephalitis.MOG antibody disease is distinguished from multiple sclerosis(MS)and Neuromyelitis Optica Disease Spectrum(NMOSD)in terms of immunopathology,clinical features,and imaging features,and is now considered as a separate Disease.This article reviews the clinical and imaging features of MOG antibody disease.

关 键 词：髓鞘少突胶质细胞糖蛋白抗体病 磁共振成像 临床特征 

分 类 号：R745.1[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]