Commensal microbiota and host metabolic divergence are associated with the adaptation of Diploderma vela to spatially heterogeneous environments  

作　　者：Wei ZHU Xiudong SHI Yin QI Xiaoyi WANG Liming CHANG Chunlin ZHAO Lifeng ZHU Jianping JIANG 

机构地区：[1]CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization&Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province,Chengdu Institute of Biology,Chengdu,China [2]College of Life Sciences,Nanjing Normal University,Nanjing,China [3]University of Chinese Academy of Sciences,Beijing,China [4]Mangkang Ecological Station,Tibet Ecological Safety Monitor Network,Chengdu,China

出　　处：《Integrative Zoology》2022年第3期346-365,共20页整合动物学（英文版）

基　　金：supported by the Second Tibetan Plateau Scientific Expedition and Research Program(STEP,Grant No.2019QZKK05010503,2019QZKK04020202);National Natural Science Foundation of China(31900327).

摘　　要：Heterogeneous environment adaptation is critical to understand the species evolution and response to climate change.However,how narrow-range species adapt to micro-geographic heterogeneity has been overlooked,and there is a lack of insights from metabolism and commensal microbiota.Here,we studied the environmental adaptation for 3 geographic populations(>40 km apart)of Diploderma vela,a lizard endemic to dry-hot valleys of the Hengduan Mountain Region.The climatic boundary caused a cooler,droughtier,and barren environment for northernmost population(RM)than the middle(QZK)and southernmost populations(FS).Correspondingly,significant divergences in liver and muscle metabolism and commensal microbiota were detected between RM and QZK or FS individuals,but not between QZK and FS individuals.Phospholipid composition,coenzyme level(i.e.pyridoxal and NAD^(+)),and cholesterol metabolism(e.g.androgen and estriol synthesis)constituted the major metabolic difference between RM and QZK/FS groups.FS and QZK individuals kept abundant Proteobacteria and antifungal strains,while RM individuals maintained more Firmicutes and Bacteroidota.Strong associations existed between varied host metabolite and gut microbes.How were these interpopulation variations associated to the environment adaptation were discussed.These results provided some novel insights into the environmental adaptation and implicated the consequence of climate change on narrow-range species.

关 键 词：commensal microbiota environmental heterogeneity metabolomics PHOSPHOLIPID steroid hormone temperature 

分 类 号：Q93[生物学—微生物学]