funded by Biological Breeding-Major Projects(2023ZD04076);National Science Foundation of China(32370267)。
Cotton fiber length is basically determined by wellcoordinated gene expression and phosphatidylinositol phosphates(PIPs) accumulation during fiber elongation but the regulatory mechanism governing PIPs transport remai...
Objective:To assess the changes in gene expression of activation-induced cytidine deaminase(AID)in COVID-19 patients and its relationship with the presence of autoantibodies in those ones.Methods:This retrospective st...
grants from the National Key Research and Development Program of China(2021YFC2100800);the National Natural Science Foundation of China(No.22108154,No.22138006,No.32171430,No.22278240);the Natural Science Foundation of Beijing Municipality(M21010,China);the Shuimu Tsinghua Scholar Program(2020SM097,China).
Yeast has been an indispensable host for synthesizing complex plant-derived naturalcompounds, yet the yields remained largely constrained. This limitation mainly arises from overlookingthe importance of cell and pathw...
supported by the National Natural Science Foundation of China(92354305,32321004,and 91957106 to K.H.);the Ministry of Science and Technology of the People’s Republic of China(2022YFA1304500 to K.H.).
Distinct phospholipid species display specific distribution patterns across cellular membranes,which are important for their struc-tural and signaling roles and for preserving the integrity and functionality of the pl...
supported by the National Natural Science Foundation of China(31930086 and 32172642);the National Key Research and Development(R&D)Program of China(2016YFD0400902 and 2021YFD2100505).
Light is a fundamental environmental factor for living organisms on earth—not only as a primary energy source but also as an informational signal.In fungi,light can be used as an indicator for both time and space to ...
supported by the Natural Science Foundation of Guangdong (2023B1515040016 and 2021B1515120023);the National Natural Science Foundation of China (Grant numbers 82125038,82274123 and 82174054);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program (2017BT01Y036);the Innovation Team Project of Guangdong Provincial Department of Education (2020KCXTD003)and GDUPS (2019);the National Key Research and Development Program of China (2022YFC0867400).
Psychological stress increases the susceptibility to herpes simplex virus type 1(HSV-1)infection.There is no effective intervention due to the unknown pathogenesis mechanisms.In this study we explored the molecular me...
the National Key Research and Development Program of China(2020YFA0908200);National Natural Science Foundation of China(91949203 and 22105127);Shanghai Municipal Health Commission(202140128);Shanghai Pujiang Program(21PJD045);Non-profit Central Research Institute Fund of the Chinese Academy of Medical Sciences(2019PT320001);Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20171906);GuangCi Professorship Program of Ruijin Hospital Shanghai Jiao Tong University School of Medicine.
In situ-activated therapy is a decent option for localized diseases with improved efficacies and reduced side effects,which is heavily dependent on the local conversion or activation of bioinert components.In this wor...
supported by the National Key R&D Program of China(2022YFA1303400 and 2022YFD1201700);the National Natural Science Foundation of China(32270301 and 31970300);the Jiangsu Agriculture Science and Technology Innovation Fund(CX-20-2007);the Fundamental Research Funds for the Central Universities(XUEKEN2022002).
Membrane fluidity,permeability,and surface charges are controlled by phospholipid metabolism and transport.Despite the importance of phosphatidic acid(PA)as a bioactive molecule,the mechanical properties of PA translo...
supported by the National Key Research and Development Program of China(No.2021YFC2100900);the National Natural Science Foundation of China(No.32171261);the Natural Science Foundation of Jiangsu Province(No.BK20221082);the Fundamental Research Funds for the Central Universities(No.JUSRP21940).
Phospholipase D(PLD)is an essential biocatalyst for the biological production of phosphatidylserine and phospholipid modification.However,the efficient heterologous expression of PLD is limited by its cell toxicity.In...
financially supported by Key Program of National Natural Science Foundation of China(Grant No.32230080);Dalian Science and Technology Innovation Fund(Grant No.2022JJ11CG008);National Key R&D Program of China,grant number(Grant No.2018YFC1406806).
Self-microemulsion drug delivery systems(SMEDDS)have great potential for use in food applications,but their adoption has been limited due to the high proportion of non-edible surfactants.To address this limitation,we ...