钙敏感受体基因多态性检测对卵巢癌早期诊断和侵袭转移的临床观察  

Clinical observation of calcium-sensitive receptor gene polymorphisms in early diagnosis and invasion and metastasis of ovarian cancer

作　　者：王西兵[1] 王磊[2] 徐益文 周芬 WANG Xibing;WANG Lei;XU Yiwen;ZHOU Fen(Department of Obstetrics and Gynecology, Zaozhuang Maternal and Child Health Hospital, Zaozhuang 277000,China)

机构地区：[1]枣庄市妇幼保健院妇产科,山东枣庄277000 [2]枣庄市妇幼保健院生殖医学中心,277000

出　　处：《临床肿瘤学杂志》2022年第6期549-552,共4页Chinese Clinical Oncology

摘　　要：目的为探究钙敏感受体基因多态性检测对卵巢癌早期诊断和侵袭转移的应用效果。方法选取我院于2015年8月至2017年8月收治的124例卵巢癌患者(研究组)和同时期124例健康体检者(对照组)为研究对象,比较研究组与对照组等位基因频率分布,并分析钙敏感受体rs17251221的基因型与卵巢癌临床病理特征的关系,分析基因多态性与卵巢癌预后的关系。结果研究组rs17251221位点的A/G+A/A等位基因频率明显高于对照组(P<0.05)。钙敏感受体rs17251221基因型与肿瘤大小、TNM分期、淋巴结转移有关(P<0.05),与年龄、绝经情况、AFP等无关。基因型为A/G或A/A的患者无病生存时间、总生存期均短于G/G组(P<0.05)。结论钙敏感受体rs17251221的A等位基因在卵巢癌患者中表达程度高,且临床分期越高、发生转移的患者基因为A/A+A/G型更为常见,因此进行钙敏感受体基因多态性检测对卵巢癌的早期诊断、侵袭转移有指导意义。Objective To investigate the effect of calcium sensitive receptor gene polymorphism detection on early diagnosis and invasion and metastasis of ovarian cancer.Methods One hundred and twenty-four patients with ovarian cancer admitted to our hospital from August 2015 to August 2017(study group)and 124 healthy subjects in the same period(control group)were selected as subjects.Allele frequency distribution of study group and control group were compared,and the relationship between genotype of calcium sensitive receptor rs17251221 and clinicopathological characteristics of ovarian cancer was analyzed.To analyze the relationship between gene polymorphism and prognosis of ovarian cancer.Results The A/G+A/A allele frequency of rs17251221 in the study group was significantly higher than that in the control group(P<0.05).Calcium sensitive receptor rs17251221 genotype was associated with tumor size,TNM stage and lymph node metastasis(P<0.05),but not with age,menopause,AFP,etc.The disease-free survival time and overall survival time of A/G or A/A genotypes were shorter than those of G/G group(P<0.05).Conclusion The A allele of calcium-sensitive receptor rs17251221 is highly expressed in ovarian cancer patients,and the higher the clinical stage is,the more common in patients with metastasis is A/A+A/G type.Therefore,the detection of calcium-sensitive receptor gene polymorphism has guiding significance for the early diagnosis,invasion and metastasis of ovarian cancer.

关 键 词：卵巢癌 钙敏感受体基因 多态性检测 早期诊断 侵袭转移 

分 类 号：R737.31[医药卫生—肿瘤]