直径﹤3 cm原发性肝癌的超声造影影像特征与肿瘤分化程度的关系  

Relationship between contrast-enhanced ultrasound imaging features and tumor differentiation of primary liver cancer with diameter of<3 cm

作　　者：李芳[1] 程军涛[2] 王衍森 LI Fang;CHENG Juntao;WANG Yansen(Department of Ultrasound,the Fifth People’s Hospital of Anyang,Anyang 455000,He’nan,China;Department of Critical Care Medicine,the People’s Hospital of Anyang City,Anyang 455000,He’nan,China)

机构地区：[1]安阳市第五人民医院超声科,河南安阳455000 [2]安阳市人民医院重症医学部,河南安阳4550000

出　　处：《癌症进展》2022年第10期1065-1068,共4页Oncology Progress

摘　　要：目的探讨直径﹤3 cm原发性肝癌的超声造影影像特征与肿瘤分化程度的关系。方法选取104例原发性肝癌患者,按分化程度分为高分化组(n=28)、中分化组(n=40)、低分化组(n=36),均接受超声造影检查,评估超声造影诊断原发性肝癌与病理学诊断结果的一致性。比较不同分化程度原发性肝癌患者超声造影模式下动脉相(5~30 s)、门脉相(31~120 s)、延迟相(121~360 s)病灶的增强强度,比较不同分化程度原发性肝癌患者的增强模式、增强时间、达峰时间、消退时间。结果104例原发性肝癌患者经超声造影检出95例,诊断准确度为91.35%(95/104),与病理诊断结果具有较高一致性(Kappa=0.913)。3组患者延迟相增强强度比较,差异有统计学意义(P﹤0.05),延迟相增强强度减退至低增强,其中低分化组患者表现更为显著。3组患者增强模式比较,差异有统计学意义(P﹤0.01),其中低、中分化组患者增强模式以快进快出为主,快进慢出较少见;高分化组患者增强模式呈快进快出或快进慢出的特点。3组患者增强时间、达峰时间、消退时间比较,差异均有统计学意义(P﹤0.01),其中高分化组患者增强时间、达峰时间、消退时间均长于低、中分化组,中分化组患者增强时间、达峰时间、消退时间均长于低分化组,差异均有统计学意义(P﹤0.05)。结论原发性肝癌超声造影影像特征与其分化程度关系密切,不同分化程度原发性肝癌的超声造影征象各有特点,可为临床诊断与分级提供可靠的依据。Objective To investigate the relationship between the contrast-enhanced ultrasound imaging features and the degree of tumor differentiation in primary liver cancer with diameter of<3 cm.Method A total of 104 patients with primary liver cancer were selected and divided into highly differentiated group(n=28),moderately differentiated group(n=40),and poorly differentiated group(n=36)according to the degree of differentiation.All patients underwent contrastenhanced ultrasonography to evaluate the consistency of contrast-enhanced ultrasonography in diagnosing primary liver cancer and pathological diagnosis.To compare the enhancement intensity of lesions in arterial phase(5-30 s),portal phase(31-120 s)and delayed phase(121-360 s)in patients with different degrees of differentiation of primary liver cancer under contrast-enhanced ultrasound mode.To compare the enhancement pattern,enhancement time,peak time,and regression time of primary liver cancer patients with different degrees of differentiation.Result Among 104 patients with primary liver cancer,95 cases were detected by contrast-enhanced ultrasonography,and the diagnostic accuracy was 91.35%(95/104),which was highly consistent with the pathological diagnosis results(Kappa=0.913).There was statistically significant difference in the delayed phase enhancement intensity among the three groups(P<0.05),the delayed phase enhancement intensity decreased to low enhancement,and the patients in the poorly differentiated group showed more significant performance.There was statistically significant difference in the delayed phase enhancement intensity among the three groups(P<0.05),the delayed phase enhancement intensity decreased to low enhancement,and the patients in the poorly differentiated group showed more significant performance.There were significant differences in the enhancement time,peak time and resolution time among the three groups(P<0.01).The enhancement time,peak time,and regression time of the patients in the group were longer than those in the poorly differe

关 键 词：原发性肝癌 超声造影 分化程度 影像学特征 

分 类 号：R735.7[医药卫生—肿瘤]