倾向性评分匹配法辅助评估不同肿瘤细胞减灭术治疗上皮性卵巢癌的效果  

Propensity score matching method to assist in evaluating the effect of different cytoreductive surgeries in the treatment of epithelial ovarian cancer

作　　者：张利珍 周传亚 张新丽 ZHANG Lizhen;ZHOU Chuanya;ZHANG Xinli(Department of Gynecology,Puyang Maternity and Child Care Centers,Puyang 457000,He’nan,China)

机构地区：[1]濮阳市妇幼保健院妇科,河南濮阳4570000

出　　处：《癌症进展》2022年第11期1176-1179,共4页Oncology Progress

摘　　要：目的探讨倾向性评分匹配法辅助评估不同肿瘤细胞减灭术治疗上皮性卵巢癌(EOC)的效果。方法依据治疗方法将163例EOC患者分为观察组(n=75)和对照组(n=88),观察组患者给予间歇性肿瘤细胞减灭术(IDS)治疗,对照组患者给予初始肿瘤细胞减灭术(PDS)治疗。采用1∶1最邻近匹配法、Match Tolerance(用来设置倾向性评分匹配标准)为0.02对患者进行倾向性评分匹配,最终两组成功匹配47对。比较两组患者的减瘤满意率、临床疗效、血清肿瘤标志物[糖类抗原125(CA125)、人附睾上皮分泌蛋白4(HE4)、血管内皮生长因子(VEGF)]水平、不良反应发生情况和随访1年复发情况。结果观察组患者的减瘤满意率为76.60%,明显高于对照组患者的53.19%(P﹤0.05)。观察组患者的临床疗效明显优于对照组(P﹤0.01),治疗总有效率为78.72%,明显高于对照组患者的53.19%(P﹤0.01)。治疗完成时,两组患者CA125、HE4、VEGF水平均明显低于本组治疗前(P﹤0.01),且观察组患者CA125、HE4、VEGF水平均明显低于对照组(P﹤0.01)。观察组患者的不良反应总发生率为25.53%,明显低于对照组患者的55.32%(P﹤0.01)。随访1年,观察组患者的复发率为2.13%,与对照组患者的6.38%无明显差异(P﹥0.05)。结论与PDS相比,IDS可明显提高EOC患者减瘤满意率,改善临床疗效,降低肿瘤标志物水平,减少不良反应。倾向性评分匹配法减少了数据偏倚,提高了研究结果的可信度。Objective To investigate the effect of propensity score matching method to assist in evaluating the effect of different cytoreductive surgeries in the treatment of epithelial ovarian cancer(EOC).Method According to the treat-ment method,163 EOC patients were divided into observation group(n=75)and control group(n=88).The patients in the observation group were treated with interval debulking surgery(IDS),and the patients in the control group were treated with primary debulking surgery(PDS).The 1∶1 nearest neighbor matching method was used,and the Match Tolerance(used to set the propensity score matching standard)was 0.02 for propensity score matching.Finally,47 pairs of two groups were successfully matched.The tumor cytoreduction satisfaction rate,clinical efficacy,serum tumor marker[car-bohydrate antigen 125(CA125),human epididymis protein 4(HE4),vascular endothelial growth factor(VEGF)]levels,incidence of adverse reactions and recurrence after 1-year follow-up were compared between the two groups.Result The satisfaction rate of tumor cytoreduction in the observation group was 76.60%,which was significantly higher than 53.19%in the control group(P<0.05).The clinical efficacy of the observation group was better than that of the control group(P<0.01),and the total effective rate was 78.72%,which was significantly higher than 53.19%of the control group(P<0.01).At the completion of treatment,the levels of CA125,HE4 and VEGF in both groups were significantly lower than those before treatment(P<0.01),with lower levels in observation group than those in the control group(P<0.01).The total incidence of adverse reactions in the observation group was 25.53%,which was significantly lower than 55.32%in the control group(P<0.01).After 1-year follow-up,the recurrence rate of the observation group was 2.13%,which was not significantly different from 6.38%of the control group(P>0.05).Conclusion Compared with PDS,IDS can signifi-cantly increase the satisfaction rate of tumor debulking in EOC patients,improve clinical efficacy,r

关 键 词：上皮性卵巢癌 肿瘤细胞减灭术 倾向性评分匹配 减瘤满意率 

分 类 号：R737.31[医药卫生—肿瘤]