Ki-67、表皮生长因子受体在室管膜瘤中的表达及与患者预后的关系  

Expression of Ki 67 and epidermal growth factor receptor in ependymoma and their relationship with prognosis

作　　者：王文涛 曹宁[2] 张国来[2] WANG Wentao;CAO Ning;ZHANG Guolai(Department of Neurosurgery,the Affiliated Hospital of Northwest University/Xi’an No.3 Hospital,Xi’an 710021,Shaanxi,China;Department of Neurosurgery,Yan’an University Affiliated Hospital,Yan’an 716000,Shaanxi,China)

机构地区：[1]西北大学附属医院/西安市第三医院神经外科,西安710021 [2]延安大学附属医院神经外科,陕西延安716000

出　　处：《癌症进展》2022年第11期1183-1186,共4页Oncology Progress

摘　　要：目的探讨Ki-67、表皮生长因子受体(EGFR)在室管膜瘤中的表达及与患者预后的关系。方法取84例室管膜瘤患者的肿瘤组织及相应癌旁组织(距肿瘤组织﹥3 cm),免疫组化法检测Ki-67、EGFR的表达情况。随访2年,记录患者的预后情况,室管膜瘤患者预后的影响因素采用多元Logistic回归模型分析。结果室管膜瘤患者肿瘤组织中Ki-67、EGFR阳性表达率均明显高于癌旁组织,差异均有统计学意义(P﹤0.01)。组织学分级为Ⅲ~Ⅳ级的室管膜瘤患者肿瘤组织中Ki-67、EGFR阳性表达率均明显高于Ⅰ~Ⅱ级患者,差异均有统计学意义(P﹤0.01)。随访2年,84例室管膜瘤患者预后好转68例,预后不良16例,预后好转与预后不良室管膜瘤患者肿瘤部位、组织学分级、Ki-67表达情况、EGFR表达情况比较,差异均有统计学意义(P﹤0.05)。多元Logistic回归分析结果显示,肿瘤部位为幕下、组织学分级为Ⅲ~Ⅳ级、Ki-67阳性表达、EGFR阳性表达均为室管膜瘤患者预后不良的独立危险因素(P﹤0.05)。结论Ki-67、EGFR在室管膜瘤中的阳性表达率较高,肿瘤部位为幕下、组织学分级为Ⅲ~Ⅳ级、Ki-67阳性表达、EGFR阳性表达均为室管膜瘤患者预后不良的独立危险因素。Objective To investigate the expression of Ki-67 and epidermal growth factor receptor(EGFR)in ependy-moma and their relationship with the prognosis of patients.Method The tumor tissues and corresponding adjacent tis-sues(>3 cm from the tumor tissue)of 84 patients with ependymoma were collected,and the expressions of Ki-67 and EG-FR were detected by immunohistochemistry.The patients were followed up for 2 years,and the prognosis of the patients was recorded.The influencing factors of the prognosis of patients with ependymoma were analyzed by multivariate Logis-tic regression model.Result The positive expression rates of Ki-67 and EGFR in tumor tissues of patients with ependy-moma were significantly higher than those in adjacent tissues,and the differences were statistically significant(P<0.01).The positive expression rates of Ki-67 and EGFR in the tumor tissue of ependymoma patients with histological grades III IV were significantly higher than those of patients with grades I-II,and the differences were statistically significant(P<0.01).After 2 years of follow-up,68 of 84 ependymoma patients had improved prognosis and 16 had poor prognosis.There were differences in tumor location,histological grade,Ki-67 expression and EGFR expression between improved and poor prognosis ependymoma patients,and the differences were statistically significant(P<0.05).The results of multi-variate Logistic regression analysis showed that infratentorial tumor location,histological grade III-IV,positive expres-sion of Ki-67,and positive expression of EGFR were independent risk factors for poor prognosis in patients with ependy-moma(P<0.05).Conclusion The positive expression rates of Ki-67 and EGFR in ependymoma were high.The tumor lo-cation was under the tentorium,the histological grade was III-IV,the positive expression of Ki-67 and EGFR were inde-pendent risk factors for poor prognosis in ependymoma patients.

关 键 词：KI-67 表皮生长因子受体 室管膜瘤 表达 预后 

分 类 号：R739.41[医药卫生—肿瘤]