MTHFR基因多态性与乳腺癌内分泌治疗药物引发子宫内膜病变的相关性分析  

Correlation Analysis of MTHFR Gene Polymorphisms and Endometrial Lesions Induced by Endocrine Therapy Drugs in Breast Cancer

作　　者：王书芬[1] 杜新峰[1] 程伟岩 倪猛[1] WANG Shufen;DU Xinfeng;CHENG Weiyan(Nanyang Central Hospital,Nanyang,473000)

机构地区：[1]河南省南阳市中心医院,473000 [2]郑州大学第一附属医院,450000

出　　处：《实用癌症杂志》2022年第7期1109-1112,共4页The Practical Journal of Cancer

摘　　要：目的探讨MTHFR基因多态性与乳腺癌内分泌治疗药物引发子宫内膜病变的相关性。方法选取乳腺癌患者80例。采集血液对MTHFR基因C677T、A1298C位点进行测序,比较各基因亚型与子宫内膜厚度、阴道诊刮比例之间的相关性。结果MTHFR基因CT677T位点各基因型患者间子宫内膜厚度的差异显著,具有统计学意义(P<0.05),对于CT677T,在T显性模式下,即C/T、T/T基因型患者子宫内膜厚度均大于C/C基因型患者,C/T基因型子宫内膜厚度大于C/C基因型(P<0.05)。MTHFR基因A1298C位点各基因型患者间子宫内膜厚度的差异,无统计学意义(P>0.05)。MTHFR基因CT677T位点各基因型患者间子宫内膜诊刮比例差异有统计学意义(P<0.05),其中,C/T基因型患者子宫内膜诊刮率高于A/A及C/C基因型(P<0.05)。同一基因型型患者不同药物组间子宫内膜厚度差异无统计学意义(P>0.05),对于CT677T,C/T基因患者的子宫内膜厚度比C/C和T/T型厚(P<0.05)。结论内分泌治疗药物相关子宫内膜病变的发生可能与MTHFR基因表型有关。Objective To explore the correlation between MTHFR gene polymorphisms and endometrial lesions induced by endocrine therapy drugs for breast cancer.Methods 80 breast cancer patients were selected.Blood was collected to sequence the C677T and A1298C loci of MTHFR gene,and the correlation between each gene subtype and endometrial thickness and vaginal curettage ratio was compared.Results There were significant differences in endometrial thickness among patients with different genotypes of MTHFR gene CT677T locus,with statistical significance(P<0.05).The endometrial thickness was greater than that of the C/C genotype patients,and the endometrial thickness of the C/T genotype was greater than that of the C/C genotype(P<0.05).There was no significant difference in endometrial thickness among patients with different genotypes of MTHFR gene A1298C locus(P>0.05).Conclusion The occurrence of SERMs-related endometrial lesions may be related to the MTHFR gene phenotype.

关 键 词：MTHFR基因多态性 乳腺癌 内分泌治疗药物 子宫内膜病变 

分 类 号：R737.9[医药卫生—肿瘤]