Mohs显微描记手术联合5-氨基酮戊酸光动力法对头面部基底细胞癌的临床效果分析  

Clinical Effect of Mohs Microtracing Surgery Combined with 5-aminidolone Pentonate Photodynamic Method for the Treatment of Head and Facial Basal Cell Carcinoma

作　　者：邓丽娜 秦铮 吴华娟 宋静卉 DENG Lina;QIN Zheng;WU Huajuan(Henan People's Hospital,Zhengzhou University People's Hospital,Zhengzhou,450000)

机构地区：[1]河南省人民医院,郑州大学人民医院,450000

出　　处：《实用癌症杂志》2022年第7期1208-1210,1214,共4页The Practical Journal of Cancer

摘　　要：目的探讨Mohs显微描记手术联合5-氨基酮戊酸光动力法(ALA-PDT)治疗头面部基底细胞癌(BCC)的效果。方法选取118例头面部BCC患者,按随机数字表法分为两组,各59例。对照组给予外科手术切除治疗,观察组行Mohs显微描记手术联合ALA-PDT,随访至术治疗后3个月。对比两组临床疗效、手术情况、生活质量、复发率。结果观察组治疗总有效率高于对照组,术中出血量少于对照组,手术时间长于对照组,住院时间短于对照组,差异有统计学意义(P<0.05);术前,两组生活质量综合评定问卷(GQOLI-74)各维度评分相比,差异无统计学意义(P>0.05);术后3个月,观察组GQOLI-74各维度评分高于对照组,复发率低于对照组,差异有统计学意义(P<0.05)。结论Mohs显微描记手术联合ALA-PDT虽手术时间较长,但治疗效果更佳,在减少出血量、缩短烧伤时间、降低复发率方面更具优势,有利于提升头面部BCC患者的生活质量,安全可行。Objective To investigate the effect of Mohs micrography combined with 5-aminophenolvalic acid photodynamic method(ALA-PDT)in the treatment of basal cell carcinoma of the head and face(BCC).Methods A total of 118 patients with BCC were selected and divided into 2 groups according to random number table method,59 cases in each group.The control group was treated with surgical resection,and the observation group was treated with Mohs micrography combined with ALA-PDT.The patients were followed up to 3 months after treatment.Clinical efficacy,operation situation,quality of life and recurrence rate were compared between the 2 groups.Results The total effective rate of the observation group was higher than the control group,the amount of intraoperative blood loss was less than the control group,operation time was longer than the control group,hospitalization time was shorter than the control group,the difference was statistically significant(P<0.05).Before surgery,there was no significant difference between the 2 groups in the scores of various dimensions of gQOLI-74(P>0.05).Three months after surgery,gQolI-74 score of all dimensions in the observation group was higher than that in the control group,and the recurrence rate was lower than that in the control group,with statistical significance(P<0.05).Conclusion Mohs micrography combined with ALA-PDT is more effective in reducing blood loss,shortening burn time and reducing recurrence rate,which is safe and feasible for improving the quality of life of patients with BCC.

关 键 词：头面部基底细胞癌 Mohs显微描记手术 5-氨基酮戊酸光动力法 生活质量 

分 类 号：R73-36[医药卫生—肿瘤]