会厌逐瘀汤对分化型甲状腺癌术后康复的影响研究  

Study on the effect of Huiyan Zhuyu decoction on postoperative rehabilitation of differentiated thyroid cancer

作　　者：梁优 刘兆龙[1] 杨乐[1] 黄建平[1] 余奎[2] 林满萍 李思虹 谢晓峰[1] LIANG You;LIU Zhaolong;YANG Le;HUANG Jianping;YU Kui;LIN Manping;LI Sihong;XIE Xiaofeng(Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200021, China;Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China)

机构地区：[1]上海中医药大学附属曙光医院,上海200021 [2]上海中医药大学附属龙华医院,上海200032

出　　处：《现代中西医结合杂志》2022年第11期1497-1501,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

基　　金：上海市浦东新区卫生健康委员会卫生计生科研项目(PW2019D-8)。

摘　　要：目的观察会厌逐瘀汤对分化型甲状腺癌术后康复的影响。方法选取2021年1—10月在上海中医药大学附属曙光医院和龙华医院治疗的104例分化型甲状腺癌根治术后患者,中医辨证为瘀热伤阴证。采用随机数字表法将患者分为2组,对照组52例术后第1天起给予优甲乐片口服及常规治疗,观察组52例在对照组治疗基础上给予会厌逐瘀汤治疗,2组患者均用药7 d。比较2组患者术后第1天、第7天中医症状评分,术前及术后第1天、第7天血清C反应蛋白(CRP)、白细胞介素-6(IL-6)、免疫球蛋白(IgA、IgG、IgM)水平及T淋巴细胞亚群(CD3^(+)、CD4^(+)、CD8^(+))百分率,术后7 d临床疗效。结果2组各51例完成研究。术后第7天2组颈前紧绷感、发声疲劳、口干咽燥、心悸不宁、五心烦热评分均明显低于术后第1天(P均<0.05),且观察组各项评分均明显低于对照组(P均<0.05)。2组术前、术后第1天血清CRP、IL-6、IgA、IgG、IgM水平及CD3^(+)、CD4^(+)、CD8^(+)百分率比较差异均无统计学意义(P均>0.05)。术后第7天,观察组血清CRP、IL-6水平及CD8^(+)百分率均明显低于术后第1天及同期对照组(P均<0.05),血清IgA、IgG、IgM水平及CD3^(+)百分率均明显高于术后第1天及同期对照组(P均<0.05);2组CD4^(+)百分率与术前比较及组间比较差异均无统计学意义(P均>0.05)。观察组有效率为86.3%(44/51),对照组为68.6%(35/51),观察组明显高于对照组(P<0.05)。结论分化型甲状腺癌术后患者应用会厌逐瘀汤能有效改善中医症状,减轻围手术期应激反应,保护免疫功能,有助于促进机体康复。Objective It is to observe the clinical effect of Huiyan Zhuyu decoction on postoperative rehabilitation of differentiated thyroid cancer.Methods A total of 104 patients after radical resection of differentiated thyroid cancer diagnosed as syndrome of blood stasis and heat damaging Yin who were treated in Shuguang Hospital and Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January to October 2021 were selected.The patients were divided into 2 groups by random number table method.52 cases patients in the control group were given Youjiale tablets orally and routine therapy from the first day after operation,while 52 cases in the observation group were given Huiyan Zhuyu decoction on the basis of treatment in the control group,and both groups were treated for 7 days.The traditional Chinese medicine symptom scores on the 1st and 7th days after surgery,levels of serum C-reactive protein(CRP),interleukin-6(IL-6),immune globulin protein(IgA,IgG,IgM)and the percentage of T lymphocyte subsets(CD3^(+),CD4^(+),CD8^(+))before surgery on the 1st and 7th days after surgery and the clinical efficacy at 7 days after operation were compared between the two groups.Results Fifty-one cases in each group completed the study.On the 7th day after operation,the scores of front neck tension,talk fatigue,dry mouth and throat,palpitations and restlessness,dysphoria with fever of the five centres in the two groups were significantly lower than those on the 1st day after operation(all P<0.05),and the scores of the observation group were significantly lower than those of the control group(P<0.05).There was no significant difference in the levels of serum CRP,IL-6,IgA,IgG,IgM,and the percentages of CD3^(+),CD4^(+),and CD8^(+)between the two groups before operation and on the first day after operation(all P>0.05).On the 7th day after operation,the levels of serum CRP,IL-6 and CD8^(+)percentage in the observation group were significantly lower than those on the 1st day after operation and in the control g

关 键 词：会厌逐瘀汤 甲状腺癌术后 加速康复 应激反应 免疫 

分 类 号：R736.1[医药卫生—肿瘤]