丁苯酞氯化钠注射液联合双联抗血小板药物治疗进展性脑梗死的效果  

Effects of Butylphthalide Sodium Chloride Injection Combined with Dual Antiplatelet Drugs in Progressive Cerebral Infarction

作　　者：薛记红 陈敏 刘雷风 XUE Jihong;CHEN Min;LIU Leifeng(Department of Internal Medicine,Nanyang Wancheng District First People’s Hospital,Nanyang 473000,China;Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]南阳市宛城区第一人民医院内一科,河南南阳473000 [2]郑州大学第一附属医院神经内科,河南郑州450000

出　　处：《河南医学研究》2022年第13期2430-2434,共5页Henan Medical Research

摘　　要：目的研究丁苯酞氯化钠注射液联合双联抗血小板药物治疗进展性脑梗死(PCI)患者的效果。方法选取2020年1月至2021年1月南阳市宛城区第一人民医院收治的104例PCI患者,随机分为A组、B组,每组52例。B组接受氯吡格雷、阿司匹林治疗,A组接受丁苯酞氯化钠注射液联合氯吡格雷、阿司匹林治疗。比较两组临床疗效、治疗前后Barthel指数(BI)、美国国立卫生院卒中量表(NIHSS)、简易精神状态检查量表(MMSE)评分、凝血四项指标[凝血酶原(PT)、活化部分凝血活酶时间(APTT)、凝血酶(TT)、血浆纤维蛋白原(Fib)]水平,脑血流动力学指标[搏动指数(PI)、血流速度(V_(mean))、收缩期峰值血流速度(V_(max))]、血清氧化应激相关指标[氧化蛋白产物(AOPP)、8-羟化脱氧鸟苷(8-oHdG)、谷胱甘肽过氧化物酶(GSH-Px)]水平。结果A组总有效率高于B组(P<0.05);治疗后A组NIHSS评分低于B组,BI、MMSE评分高于B组(P<0.05);A组治疗后PT、APTT、TT水平高于B组,Fib水平低于B组(P<0.05);A组治疗后PI值低于B组,V_(mean)、V_(max)值高于B组(P<0.05);治疗后A组血清8-oHdG、AOPP水平低于B组,GSH-Px水平高于B组(P<0.05)。结论丁苯酞氯化钠注射液联合双联抗血小板药物治疗PCI患者效果显著,可有效改善神经、凝血功能及脑部微循环,缓解机体氧化应激状态,提升日常生活能力,促进病情恢复。Objective To study the effect of butylphthalide sodium chloride injection combined with dual antiplatelet drugs in patients with progressive cerebral infarction(PCI).Methods A total of 104 PCI patients admitted to the Nanyang Wancheng District First People’s Hospital from January 2020 to January 2021 were selected and randomly divided into group A and group B,with 52 cases in each group.Group B received clopidogrel and aspirin,and group A received butylphthalide sodium chloride injection combined with clopidogrel and aspirin.The clinical efficacy,Barthel index(BI),National Institutes of Health stroke scale(NIHSS),mini-mental state examination(MMSE)scores,four coagulation indexes[prothrombin(PT),activated partial thromboplastin time(APTT),thrombin(TT),plasma fibrinogen(Fib)]levels,cerebral hemodynamic indexes[pulsatile index(PI),blood flow velocity(V_(mean)),peak systolic blood flow velocity(V_(max))],serum oxidative stress-related indicators[oxidative protein product(AOPP),8-hydroxydeoxyguanosine(8-oHdG),glutathione peroxidase(GSH-Px)]levels after treatment were compared between the two groups.Results The total effective rate of group A was higher than that of group B(P<0.05).After treatment,the NIHSS score in group A was lower than that in group B,and the BI and MMSE scores in group A were higher than those in group B(P<0.05).After treatment,the levels of PT,APTT and TT in group A were higher than those in group B,and the level of Fib was lower than that in group B(P<0.05).After treatment,the serum levels of 8-oHdG and AOPP in group A were lower than those in group B,and the level of GSH-Px was higher than that in group B(P<0.05).Conclusion Butylphthalide sodium chloride injection combined with dual antiplatelet drugs has a significant effect in the treatment of patients with PCI,which can effectively improve the nerve,coagulation function and brain microcirculation,relieve the oxidative stress state of the body,improve the ability of daily life,and promote the recovery of the disease.

关 键 词：进展性脑梗死 丁苯酞 双联抗血小板 凝血四项 

分 类 号：R743.3[医药卫生—神经病学与精神病学]