Interruption of Klf5 acetylation in basal progenitor cells promotes luminal commitment by activating Notch signaling  

作　　者：Baotong Zhang Siyuan Xia Mingcheng Liu Xiawei Li Shimin Shuai Wei Tao Yixiang Li Jianping Jenny Ni Wei Zhou Lan Liao Jianming Xu Jin-Tang Dong 

机构地区：[1]Department of Human Cell Biology and Genetics,Southern University of Science and Technology School of Medicine,Shenzhen,Guangdong 518055,China [2]Department of Hematology and Medical Oncology,Emory University School of Medicine,Atlanta,GA 30322,USA [3]Winship Cancer Institute,Emory University,Atlanta,GA 30322,USA [4]Department of Human Cell Biology and Genetics,Southern University of Science and 7.Department of Molecular and Cellular Biology,Baylor College of Medicine,Houston,TX,USA

出　　处：《Journal of Genetics and Genomics》2022年第6期579-582,共4页遗传学报（英文版）

基　　金：supported by the grant JCYJ20200109141229255 from Science, Technology and Innovation Commission of Shenzhen Municipality;supported by grants R01CA171189 and R01CA193455 from the National Cancer Institute, National Institutes of Health;supported in part by the Emory Integrated Genomics Core, Integrated Cellular Imaging Core Facility, Winship Research Pathology Core, and Transgenic Mouse and Gene Targeting Core of Emory University Winship Cancer Institute and NIH/NCI under award number P30CA138292。

摘　　要：Prostate homeostasis and regeneration rely on the proper function of adult stem/progenitor cells(Ousset et al., 2012), which have also been considered as potential cells of origin for prostate cancer(Visvader, 2011) given their key positions in the lineage hierarchy and self-renewal capability. Accumulating evidence reveals the existence of multipotent progenitor cells in both basal and luminal cells.

关 键 词：PROGENITOR LUMINAL 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]