精神分裂症MK-801动物模型的研究进展  

Recent advance in dizocilpine MK-801 animal models of schizophrenia

作　　者：张博音 曹钰莹 马嘉悦 赵云帆 霍春月[1] Zhang Boyin;Cao Yuying;Ma Jiayue;Zhao Yunfan;Huo Chunyue(Yanjing College of Capital Medical University,Beijing 101300,China)

机构地区：[1]首都医科大学燕京医学院,北京101300

出　　处：《中华神经医学杂志》2022年第6期642-645,共4页Chinese Journal of Neuromedicine

基　　金：首都医科大学燕京医学院科研培育基金(20kyqd01)。

摘　　要：精神分裂症是一种严重且常见的精神疾病,致病原因目前尚不明确。地卓西平马来酸盐(MK-801)模型是被广泛应用的精神分裂症动物模型,能覆盖精神分裂症的主要内表型。本文围绕MK-801动物模型的发病机制、造模方法、行为学特点等内容展开综述,以期为精神分裂症的相关研究提供思路。Schizophrenia(SCZ)is a kind of devastating and common neuropsychiatric disorder,and its etiology remains to be determined.Dizocilpine MK-801 animal models,which can cover the major endophenotypes of SCZ,are widely used in the study of SCZ.In this paper,the research status is reviewed about the pathogenic mechanism,modeling method,behavioral characteristics of MK-801 animal models of SCZ in recent years in order to provide some possible ideas for the study of SCZ.

关 键 词：精神分裂症 地卓西平马来酸盐 谷氨酸 动物模型 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R-332[医药卫生—临床医学]