烟雾病潜在生物标记物的研究进展  

Recent advance in potential biomarkers of moyamoya disease

作　　者：宋平安 胡国文[1] 李韶光 许江 郭华[1] 吴雷[1] Song Ping'an;Hu Guowen;Li Shaoguang;Xu Jiang;Guo Hua;Wu Lei(Department of Neurosurgery,Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院神经外科,南昌330006

出　　处：《中华神经医学杂志》2022年第5期516-522,共7页Chinese Journal of Neuromedicine

基　　金：江西省自然科学基金(20192BAB205077)。

摘　　要：烟雾病是一种慢性进行性闭塞性脑血管病,以颈内动脉末端进行性闭塞伴颅底异常血管网形成为特征。其发病机制目前尚不完全清楚,主要认为与遗传因素、环境因素和免疫炎症反应等相关。相关生物标记物的发现可为阐明烟雾病的发病机制、实现烟雾病的早期诊疗提供希望。笔者现从与烟雾病相关的编码基因、非编码RNA及蛋白角度出发,阐述其参与烟雾病发生发展的可能分子机制,以深入阐明其作为烟雾病生物标记物的价值。Moyamoya disease is a chronic progressive occlusive cerebrovascular disease characterized by progressive occlusion of the terminal internal carotid artery with formation of an abnormal vascular network at the skull base.The pathogenesis of the disease is not fully understood and is mainly thought to be associated with genetic factors,environmental factors and immune inflammatory response.The discovery of relevant biomarkers may provide hope for elucidation of pathogenesis of moyamoya disease and the early diagnosis and treatment of it.From the perspectives of coding gene,non-coding RNA and protein related to moyamoya disease,the possible molecular mechanisms involved in the occurrence and development of moyamoya disease are elaborated to further clarify their value as biomarkers of moyamoya disease.

关 键 词：烟雾病 生物标记物 编码基因 非编码RNA 蛋白 

分 类 号：R743[医药卫生—神经病学与精神病学]