胆红素与精神分裂症的相关研究进展  

Recent advance in correlation between bilirubin and schizophrenia

作　　者：张双阳 伍海姗[2] 郭文斌[2] 陈茜[1] 曾翠溶 曹婷 张毕奎[1] 蔡骅琳[1] Zhang Shuangyang;Wu Haishan;Guo Wenbin;Chen Qian;Zeng Cuirong;Cao Ting;Zhang Bikui;Cai Hualin(Department of Pharmacy,Second Xiangya Hospital of Central South University,Institute of Clinical Pharmacy,Central South University,Changsha 410000,China;National Clinical Research Center for Mental Disorders,Department of Psychiatry,Second Xiangya Hospital of Central South University,Changsha 410000,China)

机构地区：[1]中南大学湘雅二医院药学部,中南大学临床药学研究所,长沙410011 [2]中南大学湘雅二医院精神病学科,国家精神心理疾病临床医学研究中心,长沙410011

出　　处：《中华神经医学杂志》2022年第5期528-532,共5页Chinese Journal of Neuromedicine

基　　金：湖南省自然科学基金(2021JJ30922);湖南省卫健委科研课题(202113010595);长沙市自然科学基金(kq2007045);中南大学湘雅二医院医疗新技术项目((2021)94)。

摘　　要：近期研究发现人体内高水平胆红素与精神分裂症存在一定的相关性:新生儿时期高水平胆红素可增加成人罹患精神分裂症的风险,合并高胆红素血症的成年精神分裂症患者精神症状更重。与其他类型精神疾病患者和正常人群相比,精神分裂症患者的胆红素水平普遍更高,并且这些较高水平的胆红素与精神分裂症的急性发作、阳性症状及不良预后相关。本文现综述胆红素与精神分裂症的关系及其潜在的病理生理机制,以期为精神分裂症的发病机制及辅助诊断研究提供新的方向。Recently,accumulating evidence suggests that high bilirubin level is involved in the pathophysiology of schizophrenia.High bilirubin level during early childhood may increase the risk of being suffered from schizophrenia after adulthood,and schizophrenia patients with high bilirubin level have aggravated psychiatric symptoms.As compared with other psychiatric patients and general population,schizophrenia patients usually have relatively higher bilirubin level;high bilirubin level is associated with acute psychotic states,positive symptoms,and poor prognosis in patients with schizophrenia.This article reviews the relation between bilirubin and schizophrenia and its potential pathophysiological mechanism in order to provide a new direction for the study of schizophrenia pathogenesis and auxiliary diagnosis.

关 键 词：胆红素 精神分裂症 中枢神经系统 抗精神病药物 

分 类 号：R749.3[医药卫生—神经病学与精神病学]