251例结肠息肉切除术后再发危险因素分析  

Analysis of risk factors of postoperative colorectal polyps recurrence in 251 patients

作　　者：赵利娜[1] 王恺疌 罗琦[1] 陶双友[1] 陈一鸣[1] 兰绍阳[1] Zhao Lina;Wang Kaijie;Luo Qi;Tao Shuangyou;Chen Yiming;Lan Shaoyang(The First Affiliated Hospital,Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学第一附属医院,广州510405

出　　处：《新医学》2022年第7期491-495,共5页Journal of New Medicine

基　　金：广东省中医药局科研项目(20221145)。

摘　　要：目的探讨结肠息肉切除术后再发的危险因素。方法回顾性分析251例结肠息肉切除术后患者再发的危险因素。结果男性、结肠息肉部位多发于全结肠、息肉个数>10个均为结肠息肉再发的危险因素(P值分别为0.009、<0.001、0.028)。再发组(160例)癌胚抗原水平高于未再发组(P=0.014),而年龄、同型半胱氨酸水平且伴有高血压者虽均高于未再发组(91例),但差异均无统计学意义(P值分别为0.076、0.077、0.077)。增生性息肉再发风险低(P=0.023)。未发现其他代谢相关因素如肥胖、糖尿病、脂肪肝、甘油三酯、LDL、尿酸、CRP与结肠息肉再发相关(P值分别为0.444、0.641、0.541、0.889、0.362、0.247、0.248)。多因素logistic回归分析进一步表明男性、息肉部位多发于全结肠与息肉再发密切相关(P值为0.033、0.003)。结论男性、结肠息肉部位多发于全结肠、息肉个数>10个均为息肉再发的危险因素,增生性息肉再发风险低。癌胚抗原水平与息肉再发相关。男性、息肉部位多发于全结肠与息肉再发密切相关。Objective To evaluate the significance of risk factors of colorectal polyps recurrence after polypectomy.Method The risk factors of colorectal polyps recurrence after polypectomy in 251 patients were retrospectively analyzed.Results Male,multiple location of colonic polyps(the whole colon)and number of polyps(>10)were the risk factors for the recurrence of colonic polyps(P=0.009,<0.001 and 0.028).Carcinoembryonic antigen(CEA)level was higher in the recurrence group than the non-recurrence group(P=0.014).Age,homocysteine level and number of patients with hypertension in the recurrence group(n=160)were also higher compared with those in the non-recurrence group(n=91),while no statistical significance was observed(P=0.076,0.077 and 0.077).The risk of hyperplastic polyps recurrence was significantly lower(P=0.023).No other metabolic factors,such as obesity,diabetes mellitus,fatty liver,triglyceride,LDL,uric acid and colorectal polyps were found to be associated with the recurrence of colonic polyps(P=0.444,0.641,0.541,0.889,0.362,0.247 and 0.248).Multivariate logistic regression analysis further showed that male and polyps located in the ascending colon were intimately correlated with colorectal polyps recurrence(P=0.033 and 0.003).Conclusions Male,multiple location of colonic polyp(the whole colon)and number of polyps(>10)are risk factors of colorectal polyps recurrence.The risk of hyperplastic polyps recurrence is relatively low.CEA level is positively associated with colorectal polyps recurrence.Male and multiple location of colonic polyp(the whole colon)are significantly associated with colorectal polyps recurrence.

关 键 词：结肠息肉 再发 危险因素 代谢综合征 同型半胱氨酸 

分 类 号：R735.34[医药卫生—肿瘤]