Recent progress onmicrofluidic devices with incorporated 1D nanostructures for enhanced extracellular vesicle(EV)separation  

作　　者：Yuting Xiong Hanyue Kang Hongzhao Zhou Liang Ma Xiaobin Xu 

机构地区：[1]Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education,Shanghai Key Lab of D&A for Metal-Functional Materials,School of Materials Science and Engineering,Tongji University,Shanghai 201804,China [2]Institute for Advanced Study,Tongji University,Shanghai 201804,China [3]State Key Laboratory of Fluid Power and Mechatronic Systems,Zhejiang University,Hangzhou 310058,China [4]School of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China

出　　处：《Bio-Design and Manufacturing》2022年第3期607-616,共10页生物设计与制造（英文）

基　　金：the Shanghai Municipal Science and Technology Major Project(No.2021SHZDZX0100);the Fundamental Research Funds for the Central Universities,China;the National Natural Science Foundation of China(No.51875518).

摘　　要：Extracellular vesicles(EVs)are lipid-bound vesicles secreted by cells into the extracellular space.There are three types of EVs,including exosomes(30–150 nm)[1],microvesicles(100–1000 nm),and apoptotic bodies(50–4000 nm).EVs are also important intercellular communication carriers in many physiological and pathological processes such as immune response,tumor invasion,and metastasis[2,3].EVs circulate in various body fluids(e.g.,peripheral blood and urine),while carrying genetic information(e.g.,proteins and nucleic acids)from the parent cells[2,4,5].Thus,their source can be identified through gene analysis[6–10].

关 键 词：INVASION URINE METASTASIS 

分 类 号：R318[医药卫生—生物医学工程] TB383.1[医药卫生—基础医学]