肝内窦后性非肝硬化性门静脉高压症的研究进展  

Research advances in post-sinusoidal non-cirrhotic portal hypertension

作　　者：陈慧婷[1,2,3] 周永健 CHEN Huiting;ZHOU Yongjian(Department of Gastroenterology,Guangzhou First People’s Hospital,Guangzhou 510180,China;Guangzhou Digestive Disease Center,Guangzhou 510180,China;Department of Gastroenterology,The Second Affiliated Hospital of South China University of Technology,Guangzhou 510180,China)

机构地区：[1]广州市第一人民医院消化内科,广州510180 [2]广州消化疾病中心,广州510180 [3]华南理工大学附属第二医院消化内科,广州510180

出　　处：《临床肝胆病杂志》2022年第7期1469-1473,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(81970507,82170585);广东省自然科学基金(2020A1515010100,2021A1515011290);广州市科技计划项目(201904010132,202102010023);广东省医学科研基金(A2020411);广州市卫健委-高新技术项目(2019GX05);广州市医学重点学科(2021-2023)。

摘　　要：门静脉高压定义为门静脉系统压力病理性增高,其最常见的原因是肝硬化,但也见于无肝硬化时,称为非肝硬化性门静脉高压。根据累及的部位,非肝硬化性门静脉高压相关疾病可分为肝前、肝内或肝后三类;肝内病因所致可进一步细分为窦前性、窦性和窦后性。本文将总结肝后及窦后性门静脉高压的特点,并详细讨论布加综合征和肝窦阻塞综合征不同分类,简述了其临床表现、发病机制、诊断和治疗等方面的研究进展。Portal hypertension(PH)is defined as the pathological increase in pressure in the portal venous system.The most common cause of PH is liver cirrhosis,but it is also observed in patients without liver cirrhosis,which is called non-cirrhotic portal hypertension.Non-cirrhotic portal hypertension can be classified in prehepatic,intrahepatic,and posthepatic types depending on the site of involvement,and the intrahepatic type can be further divided into presinusoidal,sinusoidal,and post-sinusoidal types.This article summarizes the features of posthepatic and post-sinusoidal portal hypertension,discusses in detail the different classifications of Budd-Chiari syndrome and hepatic sinusoidal obstruction syndrome,and briefly introduces the research advances in the clinical manifestations,pathogenesis,diagnosis,and treatment of these diseases.

关 键 词：非肝硬化性门静脉高压 BUDD-CHIARI综合征 肝静脉闭塞性疾病 

分 类 号：R575.2[医药卫生—消化系统]