CCNE1在高级别浆液性卵巢癌中的表达及临床意义  

Expression of CCNE1 in high-grade serous ovarian cancer and its clinical significance

作　　者：刘璐婷[1] 熊万春[1] 王晓莉[1] LIU Luting;XIONG Wanchun;WANG Xiaoli(Department of Obstetrics and Gynecology of Chengdu Second People’s Hospital,Chengdu,Sichuan 610021,China)

机构地区：[1]成都市第二人民医院妇产科,四川成都610021

出　　处：《中国优生与遗传杂志》2022年第6期1037-1039,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的 探究细胞周期蛋白E1(CCNE1)在高级别浆液性卵巢癌(HGSOC)中的表达及临床意义。方法 通过免疫组织化学的方法检测CCNE1在2015年1月至2019年1月期间本院收集的168例高级别浆液性卵巢癌患者的组织及32例正常卵巢组织中的表达情况。分析CCNE1的表达与高级别浆液性卵巢癌患者总生存期之间的关系。结果CCNE1蛋白在高级别浆液性卵巢癌组织及正常卵巢组织中阳性表达率分别为23.8%(40/168)及3.1%(1/32);CCNE1在高级别浆液性卵巢癌组织中阳性表达率显著高于癌旁组织(P<0.05);CCNE1高表达的患者中位总生存期为35.5个月,低表达患者中位总生存期为49个月,两者具有显著统计学意义(P<0.0001)。结论 CCNE1的高表达降低了高级别浆液性卵巢癌患者的总生存期。CCNE1是高级别浆液性卵巢癌的一个不良预后因子。Objective Exploring the expression and clinical significance of Cyclin E1(CCNE1) in high-grade serous ovarian cancer(HGSOC). Methods The expression of CCNE1 in the tissues of 168 patients with HGSOC and 32 normal ovarian tissues collected in our hospital from January 2014 to January 2017 was detected by immunohistochemistry. Analyzing the relationship between the expression of CCNE1 and the overall survival of HGSOC patients. Results The positive rate of CCNE1 in HGSOC tissues was 23.8(40/168), and the positive rate of CCNE1 in normal tissues was 3.1%(1/31). The expression of CCNE1 in HGSOC was higher than that of normal tissue, with statistically significant difference(P<0.05). Median overall survival time for low-expression group HGSOC was 49.0 months,while for the high expression group was 35.5months,the difference was statistically significant(P<0.0001), HR=1.38, 95%CI(0.71, 2.05). Conclusion The high expression of CCNE1 reduces the overall survival of patients with HGSOC. CCNE1 may be a poor prognostic factor for HGSOC.

关 键 词：细胞周期蛋白E1 高级别浆液性卵巢癌 生存期 预后 

分 类 号：R737.31[医药卫生—肿瘤]