血清胃蛋白酶原和胃泌素水平与幽门螺杆菌相关性消化性溃疡的相关性评价  

Evaluation of the relationship between serum pepsinogen and gastrin and helicobacter pylori associated peptic ulcer

作　　者：谢杰[1] Xie Jie(Department of Gastroenterology,Hospital of Fujian Normal University,Fuzhou 350007,China)

机构地区：[1]福建师范大学医院消化内科,福建福州350007

出　　处：《四川生理科学杂志》2022年第6期951-953,999,共4页Sichuan Journal of Physiological Sciences

摘　　要：目的:研究血清胃蛋白酶原(Pepsinogen,PG)和胃泌素(Gastrin,G)水平与幽门螺杆菌相关消化性溃疡之间的关系。方法:分别选择我院2019年12月至2021年4月收治的105例幽门螺杆菌阳性消化性溃疡患者(阳性组),106例幽门螺杆菌阴性消化溃疡患者(阴性组)以及112例健康体检者(健康体检组),对三组受试者的血清胃蛋白酶原和胃泌素水平进行检测,分析检测结果的差异。结果:三组受试者比较,阳性组患者血清PGⅠ、PGⅡ、G-17水平明显高于阴性组与健康体检组(P<0.05)。幽门螺杆菌消化性溃疡患者比较,阳性组中胃溃疡患者的血清PGⅠ、PGⅡ、G-17水平均高于阴性组中胃溃疡患者(P<0.05);阳性组中十二指肠溃疡患者的血清PGⅠ、PGⅡ、G-17水平均高于阴性组中十二指肠溃疡患者(P<0.05)。Logistic多因素回归分析显示,血清PGⅠ、PGⅡ、G-17水平与幽门螺杆菌相关性消化性溃疡之间正相关(OR>1,P<0.05)。结论:血清胃蛋白酶原、胃泌素水平与幽门螺杆菌相关性消化性溃疡之间存在相关性,可作为诊断幽门螺杆菌相关性消化性溃疡的重要危险因素。Objective:To study the relationship between serum Pepsinogen(PG)and Gastrin(G)levels and helicobacter pylori associated peptic ulcer.Methods:105 patients with helicobacter pylori positive peptic ulcer in our hospital between December 2019 and April 2021 were chose as positive group,106 patients with helicobacter pylori negative peptic ulcer as negative group and 112 cases of health checker as health group,The levels of serum pepsinogen and gastrin in the three groups were detected and the differences of the results were analyzed.Results:The levels of serum PGⅠ,PGⅡand G-17 in positive group were significantly higher than those in negative group and healthy group(P<0.05).The serum levels of PGⅠ,PGⅡand G-17 in helicobacter pylori peptic ulcer patients in positive group were higher than those in negative group(P<0.05).The levels of serum PGⅠ,PGⅡand G-17 in the positive group were higher than those in the negative group(P<0.05).Logistic multivariate regression analysis showed that serum PGⅠ,PGⅡ,G-17 levels were positively correlated with helicobacter pylori associated peptic ulcer(OR>1,P<0.05).Conclusion:There is a correlation between serum pepsinogen and gastrin levels and helicobacter pylori associated peptic ulcer,which can be used as an important risk factor for diagnosis of helicobacter pylori associated peptic ulcer.

关 键 词：幽门螺杆菌 消化性溃疡 血清胃蛋白酶原 胃泌素 

分 类 号：R57[医药卫生—消化系统]